The cellular uptake of antisense oligonucleotid of E6 mRNA into cervical cancer cells by DOPE-modified hydroxyapatite nanoparticles

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Negin Saffarzadeh; Seyed Mehdi Kalantar; Ali Jebali; Seyed Hossein Hekmatimoghaddam; Mohammad Hassan Sheikhha; Ehsan Farashahi;
  • Publisher: Mashhad University of Medical Sciences
  • Journal: Nanomedicine Journal (issn: 2322-3049, eissn: 2322-5904)
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  • Subject: Cervical cancer cells | R5-920 | Medicine (General) | Hydroxyapatite nanoparticles | DOPE | Oligonucleotide
    mesheuropmc: inorganic chemicals | technology, industry, and agriculture

Objective(s): Although several chemical and physical methods for gene delivery have been introduced, their cytotoxicity, non-specific immune responses and the lack of biodegradability remain the main issues. In this study, hydroxyapatite nanoparticles (NPs) and 1,2-diol... View more
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