publication . Article . 2016

Reactive oxygen species, health and longevity

Vittorio Emanuele Bianchi; Giancarlo Falcioni;
Open Access English
  • Published: 01 Sep 2016
  • Country: Italy
Abstract
Reactive oxygen species (ROS) are considered responsible of ageing in animal and humans. Mitochondria are both source and target of ROS. Various strategies to reduce ROS production have been considered to extend lifespan. Caloric restriction, exercise, and antioxidants are thought to be able to protect cells from structural and functional damage. However, there is evidence that ROS production has a detrimental effect on health, but at physiological levels are necessary to stimulate longevity. They play an important effect on secondary signal transduction stimulating innate immunology and mitochondriogenesis. During exercise at moderate intensity, skeletal muscle...
Persistent Identifiers
Subjects
free text keywords: reactive oxygen species, antioxidants, aging, longevity, mitochondriogenesis, vitamin C, vitamin E, caloric restriction., lcsh:Science (General), lcsh:Q1-390, Mitochondrion, Biology, Signal transduction, chemistry.chemical_classification, chemistry, Ageing, Antioxidant, medicine.medical_treatment, medicine, Muscle adaptation, media_common.quotation_subject, media_common, Muscle atrophy, medicine.symptom, Gerontology, Endocrinology, medicine.medical_specialty, Internal medicine
223 references, page 1 of 15

9. Pamplona R, Portero-Otin M, Riba D, et al. (1998) Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J Lipid Res 39: 1989-1994.

10. Pamplona R, Barja G, Portero-Otin M (2002) Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann N Y Acad Sci 959: 475-490.

11. Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78: 547-581. [OpenAIRE]

12. Stadtman ER (1992) Protein oxidation and aging. Science 257: 1220-1224. [OpenAIRE]

13. Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120: 483-495. [OpenAIRE]

14. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95. [OpenAIRE]

15. Lobo V, Patil A, Phatak A, et al. (2010) Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 4: 118-126. [OpenAIRE]

16. Liochev SI (2013) Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 60: 1-4. [OpenAIRE]

17. Cencioni C, Spallotta F, Martelli F, et al. (2013) Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci 14: 17643-17663. [OpenAIRE]

18. Brandes RP, Fleming I, Busse R (2005) Endothelial aging. Cardiovasc Res 66: 286-294.

19. Sohal RS, Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273: 59-63. [OpenAIRE]

20. Suliman HB, Piantadosi CA (2014) Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. Curr Pharm Des 20: 5653-5662. [OpenAIRE]

21. Zuo L, He F, Sergakis GG, et al. (2014) Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol 307: L205-218.

22. Nathan C, Cunningham-Bussel A (2013) Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol 13: 349-361.

23. Kaeberlein M, Rabinovitch PS, Martin GM (2015) Healthy aging: The ultimate preventative medicine. Science 350: 1191-1193.

223 references, page 1 of 15
Related research
Abstract
Reactive oxygen species (ROS) are considered responsible of ageing in animal and humans. Mitochondria are both source and target of ROS. Various strategies to reduce ROS production have been considered to extend lifespan. Caloric restriction, exercise, and antioxidants are thought to be able to protect cells from structural and functional damage. However, there is evidence that ROS production has a detrimental effect on health, but at physiological levels are necessary to stimulate longevity. They play an important effect on secondary signal transduction stimulating innate immunology and mitochondriogenesis. During exercise at moderate intensity, skeletal muscle...
Persistent Identifiers
Subjects
free text keywords: reactive oxygen species, antioxidants, aging, longevity, mitochondriogenesis, vitamin C, vitamin E, caloric restriction., lcsh:Science (General), lcsh:Q1-390, Mitochondrion, Biology, Signal transduction, chemistry.chemical_classification, chemistry, Ageing, Antioxidant, medicine.medical_treatment, medicine, Muscle adaptation, media_common.quotation_subject, media_common, Muscle atrophy, medicine.symptom, Gerontology, Endocrinology, medicine.medical_specialty, Internal medicine
223 references, page 1 of 15

9. Pamplona R, Portero-Otin M, Riba D, et al. (1998) Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J Lipid Res 39: 1989-1994.

10. Pamplona R, Barja G, Portero-Otin M (2002) Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann N Y Acad Sci 959: 475-490.

11. Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78: 547-581. [OpenAIRE]

12. Stadtman ER (1992) Protein oxidation and aging. Science 257: 1220-1224. [OpenAIRE]

13. Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120: 483-495. [OpenAIRE]

14. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95. [OpenAIRE]

15. Lobo V, Patil A, Phatak A, et al. (2010) Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 4: 118-126. [OpenAIRE]

16. Liochev SI (2013) Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 60: 1-4. [OpenAIRE]

17. Cencioni C, Spallotta F, Martelli F, et al. (2013) Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci 14: 17643-17663. [OpenAIRE]

18. Brandes RP, Fleming I, Busse R (2005) Endothelial aging. Cardiovasc Res 66: 286-294.

19. Sohal RS, Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273: 59-63. [OpenAIRE]

20. Suliman HB, Piantadosi CA (2014) Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. Curr Pharm Des 20: 5653-5662. [OpenAIRE]

21. Zuo L, He F, Sergakis GG, et al. (2014) Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol 307: L205-218.

22. Nathan C, Cunningham-Bussel A (2013) Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol 13: 349-361.

23. Kaeberlein M, Rabinovitch PS, Martin GM (2015) Healthy aging: The ultimate preventative medicine. Science 350: 1191-1193.

223 references, page 1 of 15
Related research
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