publication . Other literature type . Article . 2018

Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor

dasom shin; H.Bae;
Open Access
  • Published: 01 Apr 2018
  • Publisher: MDPI AG
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE a...
Medical Subject Headings: integumentary system
free text keywords: Toxicology, Health, Toxicology and Mutagenesis, Article, atopic dermatitis (AD), house dust mite extract (DFE), 2,4-dinitrochlorobenzene (DNCB), bee venom phospholipase A2 (bvPLA2), skin inflammation, CD206, mannose receptor, Medicine, R
31 references, page 1 of 3

1. Brown, S.; Reynolds, N.J. Atopic and non-atopic eczema. BMJ 2006, 332, 584-588. [CrossRef] [PubMed]

2. Berke, R.; Singh, A.; Guralnick, M. Atopic dermatitis: An overview. Am. Fam. Phys. 2012, 86, 35-42.

3. Silverberg, J.I.; Kleiman, E.; Lev-Tov, H.; Silverberg, N.B.; Durkin, H.G.; Joks, R.; Smith-Norowitz, T.A. Association between obesity and atopic dermatitis in childhood: A case-control study. J. Allergy Clin. Immunol. 2011, 127, 1180-1186, e1181. [CrossRef] [PubMed] [OpenAIRE]

4. Son, J.H.; Chung, B.Y.; Kim, H.O.; Park, C.W. Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset. J. Korean Med. Sci. 2017, 32, 1360-1366. [CrossRef] [PubMed] [OpenAIRE]

5. Akdis, C.A.; Boguniewicz, M.; Leung, D.Y.M.; Novak, N.; Simons, F.E.R.; Weidinger, S.; Akdis, M.; Eigenman, P.; Lipozencic, J.K.; Platts-Mills, T.A.E.; et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology American Academy of Allergy, Asthma and Immunology PRACTALL Consensus Report. J. Allergy Clin. Immunol. 2006, 118, 152-169. [CrossRef] [PubMed] [OpenAIRE]

6. Novak, N. New insights into the mechanism and management of allergic diseases: Atopic dermatitis. Allergy 2009, 64, 265-275. [CrossRef] [PubMed]

7. Walling, H.W.; Swick, B.L. Update on the management of chronic eczema: New approaches and emerging treatment options. Clin. Cosmet. Investig. Dermatol. 2010, 3, 99-117. [CrossRef] [PubMed] [OpenAIRE]

8. Chamlin, S.L.; Kao, J.; Frieden, I.J.; Sheu, M.Y.; Fowler, A.J.; Fluhr, J.W.; Williams, M.L.; Elias, P.M. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity. J. Am. Acad. Dermatol. 2002, 47, 198-208. [CrossRef] [PubMed] [OpenAIRE]

9. Coondoo, A.; Phiske, M.; Verma, S.; Lahiri, K. Side-effects of topical steroids: A long overdue revisit. Indian Dermatol. Online J. 2014, 5, 416-425. [CrossRef] [PubMed] [OpenAIRE]

10. Jung, K.H.; Baek, H.; Kang, M.; Kim, N.; Lee, S.Y.; Bae, H. Bee Venom Phospholipase A2 Ameliorates House Dust Mite Extract Induced Atopic Dermatitis Like Skin Lesions in Mice. Toxins 2017, 9. [CrossRef] [PubMed]

11. Castro, H.J.; Mendez-Lnocencio, J.I.; Omidvar, B.; Omidvar, J.; Santilli, J.; Nielsen, H.S., Jr.; Pavot, A.P.; Richert, J.R.; Bellanti, J.A. A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis. Allergy Asthma Proc. 2005, 26, 470-476. [PubMed] [OpenAIRE]

12. Chen, J.; Lariviere, W.R. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword. Prog. Neurobiol. 2010, 92, 151-183. [CrossRef] [PubMed]

13. Mirshafiey, A. Venom therapy in multiple sclerosis. Neuropharmacology 2007, 53, 353-361. [CrossRef] [PubMed] [OpenAIRE]

14. Park, M.H.; Choi, M.S.; Kwak, D.H.; Oh, K.W.; Yoon, D.Y.; Han, S.B.; Song, H.S.; Song, M.J.; Hong, J.T. Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-kappaB. Prostate 2011, 71, 801-812. [CrossRef] [PubMed]

15. Habermann, E. Bee and wasp venoms. Science 1972, 177, 314-322. [CrossRef] [PubMed] [OpenAIRE]

31 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue