publication . Other literature type . Article . 2018

Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor

dasom shin; H.Bae;
Open Access
  • Published: 01 Apr 2018
  • Publisher: MDPI AG
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE a...
Subjects
Medical Subject Headings: integumentary system
free text keywords: Toxicology, Health, Toxicology and Mutagenesis, Article, atopic dermatitis (AD), house dust mite extract (DFE), 2,4-dinitrochlorobenzene (DNCB), bee venom phospholipase A2 (bvPLA2), skin inflammation, CD206, mannose receptor, Medicine, R
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