publication . Article . 2014

Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats.

Divya Hitler; Parthasarathy Arumugam; Mathivanan Narayanasamy; Elangovan Vellaichamy;
Open Access English
  • Published: 01 Oct 2014 Journal: Journal of Pharmacy & Pharmacognosy Research, volume 2, issue 5, pages 129-137 (issn: 0719-4250, Copyright policy)
  • Publisher: Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA)
Context: Desmodium gangeticum (L) DC (Fabaceae; DG), a medicinal plant that grows in tropical habitats, is widely used to treat various ailments including digestive and inflammatory disorders. Aims: To investigate the possible cardioprotective activity of a DG root extract against isoproterenol (ISO)-induced left ventricular cardiac hypertrophy (LVH) in adult Wistar rats. Methods: Daily intraperitoneal administration of ISO (10 mg/kg body weight, single injection) for 7 days induced LVH in rats. The LVH rats were post-treated orally with DG (100 mg/kg body weight) for a period of 30 days. Thereafter, changes in heart weight (HW) and body weight (BW), HW/BW ratio...
free text keywords: Desmodium gangeticum, cardiac hypertrophy, collagen, isoproterenol, losartan, MMPs, colágeno, hipertrofia cardiaca, lcsh:Therapeutics. Pharmacology, lcsh:RM1-950, lcsh:Pharmacy and materia medica, lcsh:RS1-441
38 references, page 1 of 3

Beauchamp C, Fridovich I (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44: 276-287. [OpenAIRE]

Chattopadhyay A, Biswas S, Bandyopadhyay D, Sarkar C, Datta AG (2003) Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine. Mol Cell Biochem 245: 43-49.

Chopra RN, Nayer SL, Chopra IC. Glossary of Indian Medicinal Plants. 1956. Council of Scientific and Industrial Research: New Delhi.

Chow AK, Cena J, Schulz R (2007) Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature. Br J Pharmacol 152: 189-205. [OpenAIRE]

D'Armiento J (2002) Matrix metalloproteinase disruption of the extracellular matrix and cardiac dysfunction. Trends Cardiovasc Med 12: 97-101. [OpenAIRE]

Evans LC, Liu H, Pinkas GA, Thompson LP (2012) Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts. Pediatr Res 71: 25-31.

Frohlich ED (1991) Left ventricular hypertrophy: dissociation of structural and functional effects by therapy. Adv Exp Med Biol 308: 175-190. [OpenAIRE]

Gradman AH, Alfayoumi F (2006) From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease. Prog Cardiovasc Dis 48: 326- 341. [OpenAIRE]

Gutteridge JM (1982) Free radicals damage to lipids, amino acids, carbohydrates and nucleic acids, determined by TBA reactivity. Int J Biochem 14: 649-653.

Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signaling pathways. Nat Rev Mol Cell Biol 7: 589-600. [OpenAIRE]

Huang XY, Chen CX, Zhang XM, Liu Y, Wu XM, Li YM (2012) Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats. Phytomedicine 19: 193- 205.

Ko CH, Shen SC, Lee TJ, Chen YC (2005) Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. Mol Cancer Ther 4: 281-290.

Kurian GA, Paddikkala J (2009) Administration of aqueous extract of Desmodium gangeticum (L) root protects rat heart against ischemic reperfusion injury induced oxidative stress. Indian J Exp Biol 47: 129-135. [OpenAIRE]

Kurian GA, Philip S, Varghese T (2005) Effect of aqueous extract of the Desmodium gangeticum DC root in the severity of myocardial infarction. J Ethnopharmacol 97: 457-461. [OpenAIRE]

Kurian GA, Suryanarayanan S, Raman A, Padikkala J (2010) Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts. Chin Med 5:3. [OpenAIRE]

38 references, page 1 of 3
Any information missing or wrong?Report an Issue