publication . Article . 2009

Traditional herbal medicines: potential degradation of sterols and sterolins by microbial contaminants

D. du Plessis-Stoman; T.G. Downing; M. van de Venter; S. Govender;
Open Access English
  • Published: 01 Apr 2009 Journal: South African Journal of Science, volume 105, issue 3 (issn: 0038-2353, eissn: 1996-7489, Copyright policy)
  • Publisher: Academy of Science of South Africa
Abstract
Medicinal plants with a high content of sterols and sterolins, such as Bulbine natalensis (rooiwortel) and Hypoxis hemerocallidea (African potato), are commonly and inappropriately used in South Africa for the treatment of HIV/AIDS due to the inaccessibility of antiretroviral drugs. This study investigated the presence of active compounds, such as sterols and sterolins, in the herbal medicines. The research was carried out in the Nelson Mandela Metropole area. The effect of microbial contaminants isolated from the medicines on sterols and sterolins of rooiwortel extracts was assessed. Sterols and sterolins were detected in rooiwortel, raw African potatoes and on...
Persistent Identifiers
Subjects
Medical Subject Headings: food and beverages
free text keywords: traditional herbal medicine, biodegradation, microbial contaminants, active compounds, lcsh:Science, lcsh:Q, lcsh:Science (General), lcsh:Q1-390, lcsh:Social Sciences, lcsh:H, lcsh:Social sciences (General), lcsh:H1-99, Traditional medicine, Hypoxis hemerocallidea, biology.organism_classification, biology, Pseudomonas putida, Bulbine, Aspergillus, Mucor, Botany, Penicillium, Microbial biodegradation, Medicinal plants
18 references, page 1 of 2

Received 29 February. Accepted 12 December 2008.

1. Erasto P., Adebola P.O., Grierson D.S. and Afolayan A.J. (2005). An ethnobotanical study of plants used for the treatment of diabetes in the Eastern Cape province, South Africa. Afr. J. Biotechnol. 4(12), 1458-1460.

2. Bodeker G., Kabatesi D., King R. and Homsy J. (2000). A regional task force on traditional medicine and AIDS. Lancet 355, 1284. [OpenAIRE]

3. Vermani K. and Garg S. (2002). Herbal medicines for sexually transmitted diseases and AIDS. J. Ethnopharmacol. 80, 49-66.

4. Bouic P.J.D., Etsebeth S., Liebenberg R.W., Albrecht C.F., Pegel K. and van Jaarsveld P.P. (1996). Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination. Int. J. Immunopharmacol. 18, 693-700.

5. Bouic P.J.D. and Lamprecht J.H. (1999). Plant sterols and sterolins: a review of their immune modulating properties. Altern. Med. Rev. 4, 170-177.

6. Bouic P.J.D. (2002). Sterols and sterolins: new drugs for the immune system? Drug Discov. Today 7, 775-778. [OpenAIRE]

7. Breytenbach U., Clark A., Lamprecht J. and Bouic P.J.D. (2001). Flow cytometry analysis of the Th1-Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus (HIV) receiving a plant sterol/sterolin mixture. Cell Biol. Int. 25, 43-49.

8. Quilez J., Garcia-Lorda P. and Salas-Salvado J. (2003). Potential uses and benefits of phytosterols in diet: present situation and future directions. Clin. Nutr. 22, 343-351.

9. Louw C.A.M., Regnier T.J.C. and Korsten L. (2002). Medicinal bulbous plants of South Africa and their traditional relevance in the control of infectious diseases. J. Ethnopharmacol. 82, 147-154.

10. Bent S. and Ko R. (2004). Commonly used herbal medicines in the United States: a review. Am. J. Med. 116, 478-485.

11. Tona L., Kambu K., Ngimbi N., Cimanga K. and Vlietinck A.J. (1998). Antiamoebic and phytochemical screening of some Congolese medicinal plants. J. Ethnopharmacol. 61, 57-65. [OpenAIRE]

12. Adewunmi C.O., Agbedahunsi J.M., Adebajo A.C., Aladesanmi A.J., Murphy N. and Wando J. (2001). Ethno-veterinary medicine: screening of Nigerian medicinal plants for trypanocidal properties. J. Ethnopharmacol. 77, 19-24.

13. Alshawsh M.A., Mothana R.A., Al-shamahy H.A., Alsllami S.F. and Lindequist U. (2007). Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., online at http://ecam.oxfordjournals.org/cgi/ content/abstract/nem148doi:10.1093/ecam/nem148 [OpenAIRE]

14. Liang Y., Xie P. and Chan K. (2004). Quality control of herbal medicines. J. Chromatogr. B 812, 53-70.

18 references, page 1 of 2
Any information missing or wrong?Report an Issue