publication . Article . Other literature type . 2017

Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses

Jenna M. Bartley; Jenna M. Bartley; Xin Zhou; Xin Zhou; George A. Kuchel; George A. Kuchel; George M. Weinstock; George M. Weinstock; Laura Haynes; Laura Haynes;
Open Access English
  • Published: 20 Sep 2017 Journal: Frontiers in Immunology, volume 8 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Immunosenescence refers to age-related declines in the capacity to respond to infections such as influenza (flu). Caloric restriction represents a known strategy to slow many aging processes, including those involving the immune system. More recently, some changes in the microbiome have been described with aging, while the gut microbiome appears to influence responses to flu vaccination and infection. With these considerations in mind, we used a well-established mouse model of flu infection to explore the impact of flu infection, aging, and caloric restriction on the gut microbiome. Young, middle-aged, and aged caloric restricted (CR) and ad lib fed (AL) mice we...
Subjects
free text keywords: Immunology, Original Research, aging, influenza, gut microbiome, caloric restriction, cytokines, Immunologic diseases. Allergy, RC581-607, Systemic inflammation, medicine.symptom, medicine, Microbiome, Vaccination, Biology, Chemokine, biology.protein, Gut flora, biology.organism_classification, Immunosenescence, Immune system, Feces
Related Organizations
Funded by
NIH| Impact of age on CD8+ T cell immunity to respiratory infection
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01AG021600-10
  • Funding stream: NATIONAL INSTITUTE ON AGING
97 references, page 1 of 7

1 Lopez-Otin C Blasco MA Partridge L Serrano M Kroemer G. The hallmarks of aging. Cell (2013) 153:1194–217.10.1016/j.cell.2013.05.039 [OpenAIRE] [DOI]

2 Thompson WW Shay DK Weintraub E Brammer L Cox N Anderson LJ Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA (2003) 289:179–86.10.1001/jama.289.2.179 [OpenAIRE] [DOI]

3 Heron M. Deaths: leading causes for 2010. Natl Vital Stat Rep (2013) 62:1–96.

4 Bender BS Johnson MP Small PA. Influenza in senescent mice: impaired cytotoxic T-lymphocyte activity is correlated with prolonged infection. Immunology (1991) 72:514–9.2037313 [OpenAIRE] [PubMed]

5 Bender BS Taylor SF Zander DS Cottey R. Pulmonary immune response of young and aged mice after influenza challenge. J Lab Clin Med (1995) 126:169–77.7636390 [PubMed]

6 Murasko DM Jiang J. Response of aged mice to primary virus infections. Immunol Rev (2005) 205:285–96.10.1111/j.0105-2896.2005.00273.x 15882361 [OpenAIRE] [PubMed] [DOI]

7 Toapanta FR Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res (2009) 10:112.10.1186/1465-9921-10-112 19922665 [OpenAIRE] [PubMed] [DOI]

8 Lefebvre JS Lorenzo EC Masters AR Hopkins JW Eaton SM Smiley ST Vaccine efficacy and T helper cell differentiation change with aging. Oncotarget (2016) 7:33581–94.10.18632/oncotarget.9254 27177221 [OpenAIRE] [PubMed] [DOI]

9 McCay CM Crowell MF Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. Nutrition (1935) 5:155–71; discussion 72. [OpenAIRE]

10 Speakman JR Mitchell SE Mazidi M. Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone. Exp Gerontol (2016) 86:28–38.10.1016/j.exger.2016.03.011 27006163 [OpenAIRE] [PubMed] [DOI]

11 Kapahi P Kaeberlein M Hansen M. Dietary restriction and lifespan: lessons from invertebrate mod els. Ageing Res Rev (2017) 39:3–14.10.1016/j.arr.2016.12.005 [OpenAIRE] [DOI]

12 Colman RJ Beasley TM Kemnitz JW Johnson SC Weindruch R Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 5:3557.10.1038/ncomms4557 [OpenAIRE] [DOI]

13 Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 126:913–22.10.1016/j.mad.2005.03.012 [OpenAIRE] [DOI]

14 Mattison JA Roth GS Beasley TM Tilmont EM Handy AM Herbert RL Impact of ca loric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 489:318–21.10.1038/nature11432 22932268 [OpenAIRE] [PubMed] [DOI]

15 Carey JR Liedo P Harshman L Zhang Y Muller HG Partridge L Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell (2002) 1:140–8.10.1046/j.1474-9728.2002.00019.x 12882344 [OpenAIRE] [PubMed] [DOI]

97 references, page 1 of 7
Abstract
Immunosenescence refers to age-related declines in the capacity to respond to infections such as influenza (flu). Caloric restriction represents a known strategy to slow many aging processes, including those involving the immune system. More recently, some changes in the microbiome have been described with aging, while the gut microbiome appears to influence responses to flu vaccination and infection. With these considerations in mind, we used a well-established mouse model of flu infection to explore the impact of flu infection, aging, and caloric restriction on the gut microbiome. Young, middle-aged, and aged caloric restricted (CR) and ad lib fed (AL) mice we...
Subjects
free text keywords: Immunology, Original Research, aging, influenza, gut microbiome, caloric restriction, cytokines, Immunologic diseases. Allergy, RC581-607, Systemic inflammation, medicine.symptom, medicine, Microbiome, Vaccination, Biology, Chemokine, biology.protein, Gut flora, biology.organism_classification, Immunosenescence, Immune system, Feces
Related Organizations
Funded by
NIH| Impact of age on CD8+ T cell immunity to respiratory infection
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01AG021600-10
  • Funding stream: NATIONAL INSTITUTE ON AGING
97 references, page 1 of 7

1 Lopez-Otin C Blasco MA Partridge L Serrano M Kroemer G. The hallmarks of aging. Cell (2013) 153:1194–217.10.1016/j.cell.2013.05.039 [OpenAIRE] [DOI]

2 Thompson WW Shay DK Weintraub E Brammer L Cox N Anderson LJ Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA (2003) 289:179–86.10.1001/jama.289.2.179 [OpenAIRE] [DOI]

3 Heron M. Deaths: leading causes for 2010. Natl Vital Stat Rep (2013) 62:1–96.

4 Bender BS Johnson MP Small PA. Influenza in senescent mice: impaired cytotoxic T-lymphocyte activity is correlated with prolonged infection. Immunology (1991) 72:514–9.2037313 [OpenAIRE] [PubMed]

5 Bender BS Taylor SF Zander DS Cottey R. Pulmonary immune response of young and aged mice after influenza challenge. J Lab Clin Med (1995) 126:169–77.7636390 [PubMed]

6 Murasko DM Jiang J. Response of aged mice to primary virus infections. Immunol Rev (2005) 205:285–96.10.1111/j.0105-2896.2005.00273.x 15882361 [OpenAIRE] [PubMed] [DOI]

7 Toapanta FR Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res (2009) 10:112.10.1186/1465-9921-10-112 19922665 [OpenAIRE] [PubMed] [DOI]

8 Lefebvre JS Lorenzo EC Masters AR Hopkins JW Eaton SM Smiley ST Vaccine efficacy and T helper cell differentiation change with aging. Oncotarget (2016) 7:33581–94.10.18632/oncotarget.9254 27177221 [OpenAIRE] [PubMed] [DOI]

9 McCay CM Crowell MF Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. Nutrition (1935) 5:155–71; discussion 72. [OpenAIRE]

10 Speakman JR Mitchell SE Mazidi M. Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone. Exp Gerontol (2016) 86:28–38.10.1016/j.exger.2016.03.011 27006163 [OpenAIRE] [PubMed] [DOI]

11 Kapahi P Kaeberlein M Hansen M. Dietary restriction and lifespan: lessons from invertebrate mod els. Ageing Res Rev (2017) 39:3–14.10.1016/j.arr.2016.12.005 [OpenAIRE] [DOI]

12 Colman RJ Beasley TM Kemnitz JW Johnson SC Weindruch R Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 5:3557.10.1038/ncomms4557 [OpenAIRE] [DOI]

13 Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 126:913–22.10.1016/j.mad.2005.03.012 [OpenAIRE] [DOI]

14 Mattison JA Roth GS Beasley TM Tilmont EM Handy AM Herbert RL Impact of ca loric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 489:318–21.10.1038/nature11432 22932268 [OpenAIRE] [PubMed] [DOI]

15 Carey JR Liedo P Harshman L Zhang Y Muller HG Partridge L Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell (2002) 1:140–8.10.1046/j.1474-9728.2002.00019.x 12882344 [OpenAIRE] [PubMed] [DOI]

97 references, page 1 of 7
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