publication . Article . 2017

A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males

Matthew Furber; Ana Anton-Solanas; Emma Koppe; Charlotte Ashby; Michael Roberts; Justin Roberts;
Open Access English
  • Published: 01 Aug 2017
  • Publisher: Elsevier
Abstract
Mitochondrial quantity and density are associated with increased oxidative metabolism. It has been demonstrated that a hypocaloric high fat/low carbohydrate (HF/LC) diet can up-regulate transcriptional markers of mitochondrial biogenesis; this was yet to be explored in vivo subsequent to a high protein/low carbohydrate (HP/LC) diet. Thus the aims of the study were to explore such diets on transcriptional markers or mitochondrial biogenesis, body composition and resting metabolic rate (RMR). Forty-five healthy male participants were randomly assigned one of four intervention diets: eucaloric high protein low carbohydrate (PRO-EM), hypocaloric high protein low car...
Subjects
free text keywords: Low carbohydrate diet ; AMPK ; PGC-1a ; Hypocaloric ; High protein diet, 612, High protein diet, PGC-1α, AMPK, Hypocaloric, Low carbohydrate diet, Nutrition. Foods and food supply, TX341-641, Carbohydrate, High-protein diet, medicine.disease_cause, medicine, SIRT3, Basal metabolic rate, Endocrinology, medicine.medical_specialty, Diabetes mellitus, medicine.disease, Lean body mass, Internal medicine, Mitochondrial biogenesis, Biology
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