publication . Article . 2007

DHA involvement in neurotransmission process

Philippe Guesnet; Isabelle Denis; Monique Lavialle; Sylvie Vancassel; Sabah Aïd;
Open Access English
  • Published: 01 May 2007 Journal: Oléagineux (issn: 1258-8210, eissn: 1950-697X, Copyright policy)
  • Publisher: John Libbey Eurotext
  • Country: France
Abstract
The very high enrichment of the nervous system in the polyunsaturated fatty acids, arachidonic (AA, 20: 4n-6) and docosahexaenoic acids (DHA, 22: 6n-3), is dependant of the dietary availability of their respective precursors, linoleic (18: 2n-6) and_-linolenic acids (18: 3n-3). Inadequate amounts of DHA in brain membranes have been linked to a wide variety of abnormalities ranging from visual acuity and learning irregularities, to psychopathologies. However, the molecular mechanisms involved remain unknown. Several years ago, we hypothesized that a modification of DHA contents of neuronal membranes by dietary modulation could change the neurotransmission functio...
Subjects
free text keywords: acetylcholine, behaviour, brain, DHA, dopamine, central nervous system, serotonin (5-HT), Oils, fats, and waxes, TP670-699, Food Science, Biochemistry, [SDV]Life Sciences [q-bio], Docosahexaenoic acid, Monoaminergic, Neuron, medicine.anatomical_structure, medicine, Neurotransmission, Endocrinology, medicine.medical_specialty, Internal medicine, Neurochemical, Polyunsaturated fatty acid, chemistry.chemical_classification, chemistry, Cholinergic, Biology, Unsaturated fatty acid
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