publication . Article . 2013

Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Kazumasa Horikawa; Kazuyuki Fuji; Yuka Fukazawa; Shigenobu Shibata;
Open Access English
  • Published: 01 Jan 2013 Journal: Journal of Pharmacological Sciences (issn: 1347-8613, Copyright policy)
  • Publisher: Elsevier
Abstract
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-ph...
Subjects
Medical Subject Headings: genetic structuresanimal structuressense organsmusculoskeletal, neural, and ocular physiology
free text keywords: Therapeutics. Pharmacology, RM1-950, Molecular Medicine, Pharmacology, Agonist, medicine.drug_class, medicine, Receptor, Cell biology, Hamster, Circadian clock, Serotonin, In vivo, Biochemistry, Darkness, 5-HT receptor, Biology
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publication . Article . 2013

Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Kazumasa Horikawa; Kazuyuki Fuji; Yuka Fukazawa; Shigenobu Shibata;