publication . Article . 2011

Effect of nitrate poisoning on some biochemical parameters in rats

O. H. Azeez; M. B. Mahmood; J. S. Hassan;
Open Access Arabic
  • Published: 01 Dec 2011 Journal: Iraqi Journal of Veterinary Sciences, volume 25, issue 2, pages 47-50 (issn: 1607-3894, eissn: 2071-1255, Copyright policy)
  • Publisher: University of Mosul, College of Veterinary Medicine
The present study was conducted to investigate the toxicity of potassium nitrate on glucose, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the possible ameliorative effect of ascorbic acid (Vitamin C). Male Wister rats are used as experimental model divided into three groups (each of 6-8 rats) and treated for six weeks as follows: Group 1: served as control; Group 2: received 2 % potassium nitrate added to the forage and Group 3: received 2 % potassium nitrate together with 1 % ascorbic acid added to rat's forage. Nitrate treatment in group 2 leads to high significant increase levels of glucose in 3 rd , 4 th , and 5 th weeks...
Persistent Identifiers
free text keywords: Nitrate toxicity, Ascorbic acid, Biochemical parameters, lcsh:Veterinary medicine, lcsh:SF600-1100, Potassium nitrate, chemistry.chemical_compound, chemistry, Biochemistry, Nitrate, Vitamin C, Animal science, Toxicity, Cholesterol, Blood sugar, Blood chemistry
23 references, page 1 of 2

1. Muslih NJ. Clinico-electrophonocardiogeraphical and immunobiological changes in nitrate-nitrite toxicosis in sheep with and without treatment. (PhD thesis). Stavropol USSR 1991.

2. Jan A, Diane B, Andrew C, Jean-Pierre C, Eugenia D, Alessandro D D, Maria LF, Peter F, Johanna FG, Corrado L G, Philippe G, Jadwiga G, Gerhard H, Niklas J, Antonio M, Josef S, Rolaf V L, Carlos Van P, Philippe V. Nitrite as undesirable substances in animal feed. The EFSA Journal.2009;1017:1-47.

3. Kyriakidis NB, Tarantili-Georgiou K, Tsani-Batzaka E. Nitrate and nitrite content of Greek cheese. J Food Comp Analysis.1997;10:343- 349.

4. Chemlnitskii GA, Loktinov VN, Poloz DD. Veterinary Toxicology. Moscow Agric press.1987;318.

5. Majid SR. Nitrate-Nitrite poisoning in laboratory animals and sheep. (PhD thesis). College of Veterinary Medicine, University of Mosul, Iraq.1996.

6. Al-Kafajii NJ. Nitrate-Nitrite intoxication in sheep in Mosul Iraq. Iraqi J Vet Sci.1996.

7. Boukerche S, Aouacheri W, Saka S. Toxicological effects of nitrate: biological study in human and animal. Ann Biol Clin.2007;65(4):385- 91.

8. Ayo JO, Minka NS, Mamman MM. Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions. J Vet Sci.2006;7(2):127-131. [OpenAIRE]

9. Suteu R, Altuntas I, Buyukvanli B, Akturk O, Koylu H, Delibas N. The effects of diazozin on lipid peroxidation and antioxidant enzymes in rats erythrocytes: role of vitamins E and C. Toxicology and Industrial Health.2007;23(1):13-17.

10. Til HP. Short-term (4 weeks) oral toxicity in rats with nitrate added to a cereal basal diet. Interim report.1985;85:288.

11. Madhuban D, Anilava K. Ascorbic acid supplementation of diet for reduction of deltamethrin induced stress in freshwater catfish Clarias gariepinus. Chemosphere.2003;53(8):883-888.

12. Fox JG, Cohen BJ, Loew FM. Laboratory Animal Medicine. Academic press London UK.1984;19-120.

13. Bruning JL, Kintz BL. Computational Handbook of Statistics. 2ed ed.Scott Foresman and Co. Glenveiw. Illionois USA.1977;75-80,102- 138.

14. Wiechetek M, Garwacki S, Karlik W, Lewicki J, Souffrant W. Effect of nitrite on ureagenesis and carbohydrate metabolism in isolated rat hepatocytes.1993;24(3).

15. Hassan MG. Study the hematological, biochemical and histological changes in chronic nitrate poisoning in sheep. (M.Sc. Thesis). College of Veterinary Medicine, University of Mosul, Iraq.1991.

23 references, page 1 of 2
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