publication . Article . 2015

Preeminence and prerequisites of sample size calculations in clinical trials

Richa Singhal; Rakesh Rana;
Open Access English
  • Published: 01 Jan 2015 Journal: Journal of the Practice of Cardiovascular Sciences (issn: 2395-5414, eissn: 2454-2830, Copyright policy)
  • Publisher: Wolters Kluwer Medknow Publications
Abstract
The key components while planning a clinical study are the study design, study duration, and sample size. These features are an integral part of planning a clinical trial efficiently, ethically, and cost-effectively. This article describes some of the prerequisites for sample size calculation. It also explains that sample size calculation is different for different study designs. The article in detail describes the sample size calculation for a randomized controlled trial when the primary outcome is a continuous variable and when it is a proportion or a qualitative variable.
Subjects
free text keywords: Power and significance level, randomized controlled trials, sample size, Medicine, R, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
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