Preeminence and prerequisites of sample size calculations in clinical trials

Article English OPEN
Richa Singhal ; Rakesh Rana (2015)
  • Publisher: Wolters Kluwer Medknow Publications
  • Journal: Journal of the Practice of Cardiovascular Sciences (issn: 2395-5414, eissn: 2454-2830)
  • Related identifiers: doi: 10.4103/2395-5414.177301
  • Subject: Power and significance level | randomized controlled trials | sample size | Medicine | R | Surgery | RD1-811 | Diseases of the circulatory (Cardiovascular) system | RC666-701

The key components while planning a clinical study are the study design, study duration, and sample size. These features are an integral part of planning a clinical trial efficiently, ethically, and cost-effectively. This article describes some of the prerequisites for sample size calculation. It also explains that sample size calculation is different for different study designs. The article in detail describes the sample size calculation for a randomized controlled trial when the primary outcome is a continuous variable and when it is a proportion or a qualitative variable.
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