Dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone Promotes Rat Tendon Stem Cells to Differentiate Into Adipocytes

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Wan Chen; Hong Tang; Xiangzhou Liu; Mei Zhou; Jiqiang Zhang; Kanglai Tang;
(2015)
  • Publisher: Cell Physiol Biochem Press GmbH & Co KG
  • Journal: Cellular Physiology and Biochemistry (issn: 1015-8987, eissn: 1421-9778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1159/000438538
  • Subject: Dexamethasone | β-catenin | QP1-981 | Tendon stem cells | QD415-436 | Dickkopf1 | GSK-3β | Biochemistry | Physiology | Adipocytes
    mesheuropmc: hormones, hormone substitutes, and hormone antagonists

Background/Aims: Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the ruptured tendon indicates that Dex may induce tendon stem cells (TSCs) to differenti... View more
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