Targeting splicing in prostate cancer

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Antonopoulou, Effrosyni; Ladomery, Michael;
  • Publisher: MDPI
  • Journal: International Journal of Molecular Sciences, volume 19, issue 5 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC5983716, doi: 10.3390/ijms19051287
  • Subject: Chemistry | KLF6 | alternative splicing | splice switching oligonucleotides | QD1-999 | splice factors | QH301-705.5 | AR | prostate cancer | BCL2L2 | Review | ERG | splice factor kinases | VEGFA | RNA interference | Biology (General)

Over 95% of human genes are alternatively spliced, expressing splice isoforms that often exhibit antagonistic functions. We describe genes whose alternative splicing has been linked to prostate cancer; namely VEGFA, KLF6, BCL2L2, ERG, and AR. We discuss opportunities to... View more
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