Targeting Splicing in Prostate Cancer

Article English OPEN
Antonopoulou, Effrosyni ; Ladomery, Michael (2018)
  • Publisher: MDPI
  • Journal: International Journal of Molecular Sciences, volume 19, issue 5 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: pmc: PMC5983716, doi: 10.3390/ijms19051287
  • Subject: Chemistry | KLF6 | alternative splicing | splice switching oligonucleotides | QD1-999 | splice factors | QH301-705.5 | AR | prostate cancer | BCL2L2 | Review | ERG | splice factor kinases | VEGFA | RNA interference | Biology (General)

Over 95% of human genes are alternatively spliced, expressing splice isoforms that often exhibit antagonistic functions. We describe genes whose alternative splicing has been linked to prostate cancer; namely VEGFA, KLF6, BCL2L2, ERG, and AR. We discuss opportunities to develop novel therapies that target specific splice isoforms, or that target the machinery of splicing. Therapeutic approaches include the development of small molecule inhibitors of splice factor kinases, splice isoform specific siRNAs, and splice switching oligonucleotides.
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