publication . Article . 2017

A Comparative Proteomic Analysis of Erinacine A’s Inhibition of Gastric Cancer Cell Viability and Invasiveness

Hsing-Chun Kuo; Yur-Ren Kuo; Kam-Fai Lee; Meng-Chiao Hsieh; Cheng-Yi Huang; Yung-Yu Hsieh; Ko-Chao Lee; Hsiang-Lan Kuo; Li-Ya Lee; Wan-Ping Chen; ...
Open Access
  • Published: 01 Aug 2017 Journal: Cellular Physiology and Biochemistry, volume 43, pages 195-208 (issn: 1015-8987, eissn: 1421-9778, Copyright policy)
  • Publisher: S. Karger AG
Abstract
Background / Aims: Erinacine A, isolated from the ethanol extract of the Hericium erinaceus mycelium, has been demonstrated as a new alternative anticancer medicine. Drawing upon current research, this study presents an investigation of the molecular mechanism of erinacine A inhibition associated with gastric cancer cell growth. Methods: Cell viability was determined by Annexin V–FITC/propidium iodide staining and migration using a Boyden chamber assay to determine the effects of erinacine A treatment on the proliferation capacity and invasiveness of gastric cancer cells. A proteomic assay provided information that was used to identify the differentially-express...
Subjects
free text keywords: Physiology, Caspase, biology.protein, biology, Propidium iodide, chemistry.chemical_compound, chemistry, Biochemistry, Viability assay, Apoptosis, Protein kinase B, Erinacine, Immunology, Cancer cell, Cancer research, Signal transduction, Erinacine A, ROS, FAK, p70S6K, 1433S, MTUS2, QP1-981, QD415-436
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publication . Article . 2017

A Comparative Proteomic Analysis of Erinacine A’s Inhibition of Gastric Cancer Cell Viability and Invasiveness

Hsing-Chun Kuo; Yur-Ren Kuo; Kam-Fai Lee; Meng-Chiao Hsieh; Cheng-Yi Huang; Yung-Yu Hsieh; Ko-Chao Lee; Hsiang-Lan Kuo; Li-Ya Lee; Wan-Ping Chen; ...