publication . Article . 2018

Isothiocyanates: a review

Chandra Kala*; Syed Salman Ali; Nabeel Ahmad; Sadaf Jamal Gilani; Najam Ali Khan;
Open Access English
  • Published: 01 Apr 2018 Journal: Research Journal of Pharmacognosy (issn: 2345-5977, eissn: 2345-5977, Copyright policy)
  • Publisher: Iranian Society of Pharmacognosy
Abstract
Isothiocyanates (ITCs) are naturally occurring molecules belonging to highly reactive organosulphur synthons, with the general structure R–N=C=S. The precursor molecule glucosinolate anions are hydrolyzed enzymatically (under the effect of myrosinase enzymes) or unenzymatically to produce nitriles or isothiocyanates depending upon conditions such as pH and temperature. Brassicaceae  Family is known to contain abundant ITCs. A significant number of isothiocyanates has been isolated from different plant sources and some of them have been synthesized. Several isothiocyanates have demonstrated significant pharmacological activities including anti-cancer, anti-inflam...
Subjects
free text keywords: Brassicaceae, cruciferous vegetables, isothiocyanates, pharmacokinetics, pharmacological activity, Pharmacy and materia medica, RS1-441
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