publication . Article . Other literature type . 2018

Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity

Judith A. Smith; Judith A. Smith;
Open Access
  • Published: 01 Mar 2018 Journal: Frontiers in Immunology, volume 9 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Protein folding in the endoplasmic reticulum (ER) is an essential cell function. To safeguard this process in the face of environmental threats and internal stressors, cells mount an evolutionarily conserved response known as the unfolded protein response (UPR). Invading pathogens induce cellular stress that impacts protein folding, thus the UPR is well situated to sense danger and contribute to immune responses. Cytokines (inflammatory cytokines and interferons) critically mediate host defense against pathogens, but when aberrantly produced, may also drive pathologic inflammation. The UPR influences cytokine production on multiple levels, from stimulation of pa...
Subjects
Medical Subject Headings: endocrine system
free text keywords: Inflammation, medicine.symptom, medicine, Autoimmunity, medicine.disease_cause, Proinflammatory cytokine, Biology, Immune system, Unfolded protein response, Immunology, Cytokine, medicine.medical_treatment, Pattern recognition receptor, Signal transduction, Review, endoplasmic reticulum stress, infection, virus, bacteria, cytokine regulation, autoinflammatory disease, Immunologic diseases. Allergy, RC581-607
Funded by
NIH| Regulation of human immune function by 17q21 asthma risk polymorphism
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21AI121808-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Brucella epitope recognition by CD8+ T cells
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI073558-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunity
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI116453-03
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
285 references, page 1 of 19

1 O’Brien C Flower DR Feighery C. Peptide length significantly influences in vitro affinity for MHC class II molecules. Immunome Res (2008) 4:6.10.1186/1745-7580-4-6 19036163 [OpenAIRE] [PubMed] [DOI]

2 Calis JJ de Boer RJ Kesmir C. Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire. PLoS Comput Biol (2012) 8(3):e1002412.10.1371/journal.pcbi.1002412 22396638 [OpenAIRE] [PubMed] [DOI]

3 Bremel RD Homan EJ Frequency patterns of T-cell exposed amino acid motifs in immunoglobulin heavy chain peptides presented by MHCs. Front Immunol (2014) 5:541 10.3389/fimmu.2014.00541 25389426 [OpenAIRE] [PubMed] [DOI]

4 Stave JW Lindpaintner K. Antibody and antigen contact residues define epitope and paratope size and structure. J Immunol (2013) 191(3):1428–35.10.4049/jimmunol.1203198 23797669 [OpenAIRE] [PubMed] [DOI]

5 Akira S Uematsu S Takeuchi O Pathogen recognition and innate immunity. Cell (2006) 124(4):783–801.10.1016/j.cell.2006.02.015 16497588 [OpenAIRE] [PubMed] [DOI]

6 van Vliet SJ Garcia-Vallejo JJ van Kooyk Y. Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses. Immunol Cell Biol (2008) 86(7):580–7.10.1038/icb.2008.55 18679407 [OpenAIRE] [PubMed] [DOI]

7 Place DE Kanneganti TD. Recent advances in inflammasome biology. Curr Opin Immunol (2017) 50:32–8.10.1016/j.coi.2017.10.011 29128729 [OpenAIRE] [PubMed] [DOI]

8 Barber GN. STING-dependent cytosolic DNA sensing pathways. Trends Immunol (2014) 35(2):88–93.10.1016/j.it.2013.10.010 24309426 [OpenAIRE] [PubMed] [DOI]

9 Rose NR. Negative selection, epitope mimicry and autoimmunity. Curr Opin Immunol (2017) 49:51–5.10.1016/j.coi.2017.08.014 29102863 [OpenAIRE] [PubMed] [DOI]

10 Cunningham MW Post-streptococcal autoimmune sequelae: rheumatic fever and beyond. In: Ferretti JJ Stevens DL Fischetti VA, editors. Streptococcus p yogenes: Basic Biology to Clinical Manifestations [Internet]. Oklahoma: University of Oklahoma Health Sciences Center (2016).

11 Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol (1994) 12:991–1045.10.1146/annurev.iy.12.040194.005015 8011301 [OpenAIRE] [PubMed] [DOI]

12 Matzinger P. The danger model: a renewed sense of self. Science (2002) 296(5566):301–5.10.1126/science.1071059 11951032 [OpenAIRE] [PubMed] [DOI]

13 Pradeu T Cooper EL. The danger theory: 20 years later. Front Immunol (2012) 3:287.10.3389/fimmu.2012.00287 23060876 [OpenAIRE] [PubMed] [DOI]

14 Land WG Agostinis P Gasser S Garg AD Linkermann A. Transplantation and damage-associated molecular patterns (DAMPs). Am J Transplant (2016) 16(12):3338–61.10.1111/ajt.13963 27421829 [OpenAIRE] [PubMed] [DOI]

15 Kono H Rock KL How dying cells alert the immune system to danger. Nat Rev Immunol (2008) 8(4):279–89.10.1038/nri2215 18340345 [OpenAIRE] [PubMed] [DOI]

285 references, page 1 of 19
Abstract
Protein folding in the endoplasmic reticulum (ER) is an essential cell function. To safeguard this process in the face of environmental threats and internal stressors, cells mount an evolutionarily conserved response known as the unfolded protein response (UPR). Invading pathogens induce cellular stress that impacts protein folding, thus the UPR is well situated to sense danger and contribute to immune responses. Cytokines (inflammatory cytokines and interferons) critically mediate host defense against pathogens, but when aberrantly produced, may also drive pathologic inflammation. The UPR influences cytokine production on multiple levels, from stimulation of pa...
Subjects
Medical Subject Headings: endocrine system
free text keywords: Inflammation, medicine.symptom, medicine, Autoimmunity, medicine.disease_cause, Proinflammatory cytokine, Biology, Immune system, Unfolded protein response, Immunology, Cytokine, medicine.medical_treatment, Pattern recognition receptor, Signal transduction, Review, endoplasmic reticulum stress, infection, virus, bacteria, cytokine regulation, autoinflammatory disease, Immunologic diseases. Allergy, RC581-607
Funded by
NIH| Regulation of human immune function by 17q21 asthma risk polymorphism
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21AI121808-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Brucella epitope recognition by CD8+ T cells
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI073558-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunity
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI116453-03
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
285 references, page 1 of 19

1 O’Brien C Flower DR Feighery C. Peptide length significantly influences in vitro affinity for MHC class II molecules. Immunome Res (2008) 4:6.10.1186/1745-7580-4-6 19036163 [OpenAIRE] [PubMed] [DOI]

2 Calis JJ de Boer RJ Kesmir C. Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire. PLoS Comput Biol (2012) 8(3):e1002412.10.1371/journal.pcbi.1002412 22396638 [OpenAIRE] [PubMed] [DOI]

3 Bremel RD Homan EJ Frequency patterns of T-cell exposed amino acid motifs in immunoglobulin heavy chain peptides presented by MHCs. Front Immunol (2014) 5:541 10.3389/fimmu.2014.00541 25389426 [OpenAIRE] [PubMed] [DOI]

4 Stave JW Lindpaintner K. Antibody and antigen contact residues define epitope and paratope size and structure. J Immunol (2013) 191(3):1428–35.10.4049/jimmunol.1203198 23797669 [OpenAIRE] [PubMed] [DOI]

5 Akira S Uematsu S Takeuchi O Pathogen recognition and innate immunity. Cell (2006) 124(4):783–801.10.1016/j.cell.2006.02.015 16497588 [OpenAIRE] [PubMed] [DOI]

6 van Vliet SJ Garcia-Vallejo JJ van Kooyk Y. Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses. Immunol Cell Biol (2008) 86(7):580–7.10.1038/icb.2008.55 18679407 [OpenAIRE] [PubMed] [DOI]

7 Place DE Kanneganti TD. Recent advances in inflammasome biology. Curr Opin Immunol (2017) 50:32–8.10.1016/j.coi.2017.10.011 29128729 [OpenAIRE] [PubMed] [DOI]

8 Barber GN. STING-dependent cytosolic DNA sensing pathways. Trends Immunol (2014) 35(2):88–93.10.1016/j.it.2013.10.010 24309426 [OpenAIRE] [PubMed] [DOI]

9 Rose NR. Negative selection, epitope mimicry and autoimmunity. Curr Opin Immunol (2017) 49:51–5.10.1016/j.coi.2017.08.014 29102863 [OpenAIRE] [PubMed] [DOI]

10 Cunningham MW Post-streptococcal autoimmune sequelae: rheumatic fever and beyond. In: Ferretti JJ Stevens DL Fischetti VA, editors. Streptococcus p yogenes: Basic Biology to Clinical Manifestations [Internet]. Oklahoma: University of Oklahoma Health Sciences Center (2016).

11 Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol (1994) 12:991–1045.10.1146/annurev.iy.12.040194.005015 8011301 [OpenAIRE] [PubMed] [DOI]

12 Matzinger P. The danger model: a renewed sense of self. Science (2002) 296(5566):301–5.10.1126/science.1071059 11951032 [OpenAIRE] [PubMed] [DOI]

13 Pradeu T Cooper EL. The danger theory: 20 years later. Front Immunol (2012) 3:287.10.3389/fimmu.2012.00287 23060876 [OpenAIRE] [PubMed] [DOI]

14 Land WG Agostinis P Gasser S Garg AD Linkermann A. Transplantation and damage-associated molecular patterns (DAMPs). Am J Transplant (2016) 16(12):3338–61.10.1111/ajt.13963 27421829 [OpenAIRE] [PubMed] [DOI]

15 Kono H Rock KL How dying cells alert the immune system to danger. Nat Rev Immunol (2008) 8(4):279–89.10.1038/nri2215 18340345 [OpenAIRE] [PubMed] [DOI]

285 references, page 1 of 19
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publication . Article . Other literature type . 2018

Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity

Judith A. Smith; Judith A. Smith;