publication . Article . Other literature type . 2017

Cytokine Profiles of Severe Influenza Virus-Related Complications in Children

Andrew Fiore-Gartland; Angela Panoskaltsis-Mortari; Anna A. Agan; Anushay J. Mistry; Paul G. Thomas; Michael A. Matthay; Michael A. Matthay; PALISI PICFlu Investigators; Tomer Hertz; Tomer Hertz; ...
Open Access English
  • Published: 01 Nov 2017 Journal: Frontiers in Immunology, volume 8 (issn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
  • Country: United States
Abstract
Rationale: Effective immunomodulatory therapies for children with life-threatening “cytokine storm” triggered by acute influenza infection are lacking. Understanding the immune profiles of children progressing to severe lung injury and/or septic shock could provide insight into pathogenesis. Objectives: To compare the endotracheal and serum cytokine profiles of children with influenza-related critical illness and to identify their associations with severe influenza-associated complications. Methods: Children with influenza-related critical illness were enrolled across 32 hospitals in development (N = 171) and validation (N = 73) cohorts (December 2008 through Ma...
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free text keywords: influenza, cytokine, acute lung injury, septic shock, inflammation, lcsh:Immunologic diseases. Allergy, lcsh:RC581-607, Cytokine storm, medicine.disease, medicine, Immunology, business.industry, business, Lung injury, medicine.symptom, Coinfection, Interleukin 10, medicine.medical_treatment, Pathogenesis
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