publication . Article . 2012

Establishment of a blunt impact-induced brain injury model in rabbits

LI Kui; CAO Yun-xing; YANG Yong-qiang; YIN Zhi-yong; ZHAO Hui; WANG Li-jun;
Open Access English
  • Published: 01 Apr 2012 Journal: Chinese Journal of Traumatology (issn: 1008-1275, Copyright policy)
  • Publisher: Elsevier
Abstract
【Abstract】 Objective: To establish an animal model to replicate the blunt impact brain injury in forensic medicine. Methods: Twenty-four New Zealand white rabbits were randomly divided into control group (n=4), minor injury group (n=10) and severe injury group (n=10). Based on the BIM-Ⅱ Horizontal Bio-impact Machine, self-designed iron bar was used to produce blunt brain injury. Two rabbits from each injury group were randomly selected to monitor the change of intracranial pressure (ICP) during the impact-ing process by pressure microsensors. Six hours after injury, all the rabbits were dissected to observe the injury mor-phology and underwent routine pathologic...
Subjects
free text keywords: Medicine (General), R5-920
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