publication . Article . 2018

Cow’s Milk and Immune Function in the Respiratory Tract: Potential Mechanisms

Olaf Perdijk; Marloes van Splunter; Huub F. J. Savelkoul; Sylvia Brugman; R. J. Joost van Neerven; R. J. Joost van Neerven;
Open Access English
  • Published: 01 Feb 2018 Journal: Frontiers in Immunology, volume 9 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
During the last decades, the world has witnessed a dramatic increase in allergy prevalence. Epidemiological evidence shows that growing up on a farm is a protective factor, which is partly explained by the consumption of raw cow’s milk. Indeed, recent studies show inverse associations between raw cow’s milk consumption in early life and asthma, hay fever, and rhinitis. A similar association of raw cow’s milk consumption with respiratory tract infections is recently found. In line with these findings, controlled studies in infants with milk components such as lactoferrin, milk fat globule membrane, and colostrum IgG have shown to reduce respiratory infections. Ho...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Immunology, Review, raw cow’s milk, upper airways, respiratory syncytial virus, allergies, asthma, barrier functioning, immune regulation, gut–lung axis, Immunologic diseases. Allergy, RC581-607, Immune system, Raw milk, Colostrum, Allergy, medicine.disease, medicine, Lactoferrin, biology.protein, biology, Respiratory system, Respiratory tract infections, Respiratory tract, medicine.anatomical_structure
156 references, page 1 of 11

1 Bach J The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med (2002) 347:911–20.10.1056/NEJMra020100 12239261 [PubMed] [DOI]

2 Strachan DP Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax (2000) 55:S2–10.10.1136/thorax.55.suppl_1.S2 10943631 [OpenAIRE] [PubMed] [DOI]

3 Yazdanbakhsh M Kremsner PG van Ree R. Allergy, parasites, and the hygiene hypothesis. Science (2002) 296:490–4.10.1126/science.296.5567.490 11964470 [OpenAIRE] [PubMed] [DOI]

4 Yang X Gao X. Role of dendritic cells: a step forward for the hygiene hypothesis. Cell Mol Immunol (2011) 8:12–8.10.1038/cmi.2010.51 21200379 [OpenAIRE] [PubMed] [DOI]

5 Licona-Limón P Kim LK Palm NW Flavell RA. TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 14:536–42.10.1038/ni.2617 23685824 [OpenAIRE] [PubMed] [DOI]

6 Hammad H Lambrecht BN. Barrier epithelial cells and the control of type 2 immunity. Immunity (2015) 43:29–40.10.1016/j.immuni.2015.07.007 26200011 [OpenAIRE] [PubMed] [DOI]

7 Wahn U Von Mutius E. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol (2001) 107:567–74.10.1067/mai.2001.112943 11295640 [OpenAIRE] [PubMed] [DOI]

8 Brugman S Perdijk O van Neerven RJJ Savelkoul HFJ. Mucosal immune development in early life: setting the stage. Arch Immunol Ther Exp (Warsz) (2015) 63:251–68.10.1007/s00005-015-0329-y 25666708 [OpenAIRE] [PubMed] [DOI]

9 Stein RT Sherrill D Morgan WJ Holberg CJ Halonen M Taussig LM Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet (1999) 354:541–5.10.1016/S0140-6736(98)10321-5 10470697 [OpenAIRE] [PubMed] [DOI]

10 Sigurs N Aljassim F Kjellman B Robinson PD Sigurbergsson F Bjarnason R Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax (2010) 65:1045–52.10.1136/thx.2009.121582 20581410 [OpenAIRE] [PubMed] [DOI]

11 Sigurs N Bjarnason R Sigurbergsson F Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med (2000) 161:1501–7.10.1164/ajrccm.161.5.9906076 10806145 [OpenAIRE] [PubMed] [DOI]

12 Kusel MMH de Klerk NH Kebadze T Vohma V Holt PG Johnston SL Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol (2007) 119:1105–10.10.1016/j.jaci.2006.12.669 17353039 [OpenAIRE] [PubMed] [DOI]

13 Holt PG Sly P Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med (2012) 18:726–35.10.1038/nm.2768.22561836 [OpenAIRE] [PubMed] [DOI]

14 Shin JS Greer AM. The role of FcεRI expressed in dendritic cells and monocytes. Cell Mol Life Sci (2015) 72:2349–60.10.1007/s00018-015-1870-x 25715742 [OpenAIRE] [PubMed] [DOI]

15 Strickland DH Thomas JA Mok D Blank F McKenna KL Larcombe AN Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma. Mucosal Immunol (2012) 5:332–41.10.1038/mi.2012.13 22354321 [OpenAIRE] [PubMed] [DOI]

156 references, page 1 of 11
Abstract
During the last decades, the world has witnessed a dramatic increase in allergy prevalence. Epidemiological evidence shows that growing up on a farm is a protective factor, which is partly explained by the consumption of raw cow’s milk. Indeed, recent studies show inverse associations between raw cow’s milk consumption in early life and asthma, hay fever, and rhinitis. A similar association of raw cow’s milk consumption with respiratory tract infections is recently found. In line with these findings, controlled studies in infants with milk components such as lactoferrin, milk fat globule membrane, and colostrum IgG have shown to reduce respiratory infections. Ho...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Immunology, Review, raw cow’s milk, upper airways, respiratory syncytial virus, allergies, asthma, barrier functioning, immune regulation, gut–lung axis, Immunologic diseases. Allergy, RC581-607, Immune system, Raw milk, Colostrum, Allergy, medicine.disease, medicine, Lactoferrin, biology.protein, biology, Respiratory system, Respiratory tract infections, Respiratory tract, medicine.anatomical_structure
156 references, page 1 of 11

1 Bach J The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med (2002) 347:911–20.10.1056/NEJMra020100 12239261 [PubMed] [DOI]

2 Strachan DP Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax (2000) 55:S2–10.10.1136/thorax.55.suppl_1.S2 10943631 [OpenAIRE] [PubMed] [DOI]

3 Yazdanbakhsh M Kremsner PG van Ree R. Allergy, parasites, and the hygiene hypothesis. Science (2002) 296:490–4.10.1126/science.296.5567.490 11964470 [OpenAIRE] [PubMed] [DOI]

4 Yang X Gao X. Role of dendritic cells: a step forward for the hygiene hypothesis. Cell Mol Immunol (2011) 8:12–8.10.1038/cmi.2010.51 21200379 [OpenAIRE] [PubMed] [DOI]

5 Licona-Limón P Kim LK Palm NW Flavell RA. TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 14:536–42.10.1038/ni.2617 23685824 [OpenAIRE] [PubMed] [DOI]

6 Hammad H Lambrecht BN. Barrier epithelial cells and the control of type 2 immunity. Immunity (2015) 43:29–40.10.1016/j.immuni.2015.07.007 26200011 [OpenAIRE] [PubMed] [DOI]

7 Wahn U Von Mutius E. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol (2001) 107:567–74.10.1067/mai.2001.112943 11295640 [OpenAIRE] [PubMed] [DOI]

8 Brugman S Perdijk O van Neerven RJJ Savelkoul HFJ. Mucosal immune development in early life: setting the stage. Arch Immunol Ther Exp (Warsz) (2015) 63:251–68.10.1007/s00005-015-0329-y 25666708 [OpenAIRE] [PubMed] [DOI]

9 Stein RT Sherrill D Morgan WJ Holberg CJ Halonen M Taussig LM Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet (1999) 354:541–5.10.1016/S0140-6736(98)10321-5 10470697 [OpenAIRE] [PubMed] [DOI]

10 Sigurs N Aljassim F Kjellman B Robinson PD Sigurbergsson F Bjarnason R Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax (2010) 65:1045–52.10.1136/thx.2009.121582 20581410 [OpenAIRE] [PubMed] [DOI]

11 Sigurs N Bjarnason R Sigurbergsson F Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med (2000) 161:1501–7.10.1164/ajrccm.161.5.9906076 10806145 [OpenAIRE] [PubMed] [DOI]

12 Kusel MMH de Klerk NH Kebadze T Vohma V Holt PG Johnston SL Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol (2007) 119:1105–10.10.1016/j.jaci.2006.12.669 17353039 [OpenAIRE] [PubMed] [DOI]

13 Holt PG Sly P Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med (2012) 18:726–35.10.1038/nm.2768.22561836 [OpenAIRE] [PubMed] [DOI]

14 Shin JS Greer AM. The role of FcεRI expressed in dendritic cells and monocytes. Cell Mol Life Sci (2015) 72:2349–60.10.1007/s00018-015-1870-x 25715742 [OpenAIRE] [PubMed] [DOI]

15 Strickland DH Thomas JA Mok D Blank F McKenna KL Larcombe AN Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma. Mucosal Immunol (2012) 5:332–41.10.1038/mi.2012.13 22354321 [OpenAIRE] [PubMed] [DOI]

156 references, page 1 of 11
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publication . Article . 2018

Cow’s Milk and Immune Function in the Respiratory Tract: Potential Mechanisms

Olaf Perdijk; Marloes van Splunter; Huub F. J. Savelkoul; Sylvia Brugman; R. J. Joost van Neerven; R. J. Joost van Neerven;