Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

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Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Pei-Sen Huang; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen;
  • Publisher: Cell Physiol Biochem Press GmbH & Co KG
  • Journal: Cellular Physiology and Biochemistry (issn: 1015-8987, eissn: 1421-9778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1159/000443044
  • Subject: Mesenchymal stem cells | Apoptosis | Hypoxia and serum deprivation | AMPK | Signaling pathway | Adiponectin | Physiology | QP1-981 | Biochemistry | QD415-436

Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigat... View more
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