Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo

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Rahul Shukla; Ravi K. Rajpoot; Upasana Arora; Ankur Poddar; Sathyamangalam Swaminathan; Navin Khanna; Navin Khanna; Navin Khanna; (2018)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Microbiology (issn: 1664-302X)
  • Related identifiers: doi: 10.3389/fmicb.2017.02644, doi: 10.3389/fmicb.2017.02644/full
  • Subject: AG129 model | envelope protein | recombinant tetravalent vaccine | virus-like particle | dengue virus | Microbiology | QR1-502 | antibodydependent enhancement
    mesheuropmc: biochemical phenomena, metabolism, and nutrition | viruses | virus diseases

Dengue, a significant public health problem in several countries around the world, is caused by four different serotypes of mosquito-borne dengue viruses (DENV-1, -2, -3, and -4). Antibodies to any one DENV serotype which can protect against homotypic re-infection, do n... View more
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