publication . Article . Other literature type . 2019

Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility

Name: Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility
Keywords: Chemistry, QD1-999

José Rivas; J. Luis Gómez-Amoza; Yolanda Piñeiro; José Blanco-Méndez; Asteria Luzardo-Álvarez; Z. Vargas-Osorio; Francisco J. Otero Espinar; Carlos Vázquez-Vázquez;

Open Access English

Published: 19 Mar 2019 Journal: ACS Omega (issn: 2470-1343,

Publisher: American Chemical Society

Country: Spain

Summary

Abstract

The development of scaffolds with suitable physicochemical and mechanical properties allowing for the structural regeneration of injured bone and recovery of the natural biological functionality is still a challenge in the tissue engineering field. Nanostructured materials with added theranostic abilities, together with an interconnected hierarchy of pores, offer the possibility to provide a new generation of bone implants. In this work, scaffolds with highly porous and resistant threedimensional structures have been successfully developed by homogeneously embedding mesoporous silica nanostructures in a bioactive matrix of chitosan/κ-carrageenan. Moreover, magne...

doi: 10.1021/acsomega.8b03676

handle: 10347/21348

Subjects

free text keywords: Chemistry, QD1-999, Surface roughness, Tissue engineering, Chitosan, chemistry.chemical_compound, Nanotechnology, Nanoparticle, Nanostructure, Mesoporous material, Mesoporous silica, Materials science, Scaffold

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