Construction of non-viral vector (mPEG5k-PCL1.2k)1.4-g-PEI10k and its gene delivery efficacy in vitro

Article Chinese OPEN
Wei HUANG; Ming LV; Zhong-gao GAO; Ming-ji JIN; Fei-fei YANG; Yu-li WANG;
(2011)
  • Publisher: Editorial Board of Medical Journal of Chinese People's Liberation Army
  • Journal: Medical Journal of Chinese People's Liberation Army (issn: 0577-7402)
  • Publisher copyright policies & self-archiving
  • Subject: non-viral vectors; gene therapy; plasmid; transfection | Medicine | R | Medicine (General) | R5-920

Objective To construct(mPEG5k-PCL1.2k)1.4-g-PEI10k,a copolymer designed as delivery vector for non-viral gene therapy,and explore its cytotoxicity and efficacy in delivery of plasmid DNA(pDNA).Methods The copolymer,mPEG5k-PCL1.2k-OH,was prepared by ring-opening polymeri... View more
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