publication . Article . 2003

immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide

Hori, Y.; Sato, S.; Yamate, J.; Masaaki KURASAKI; Nishihira, J.; Hosokawa, T.; Fujita, H.; Saito, T.;
Open Access
  • Published: 01 Jan 2003 Journal: European Journal of Histochemistry, volume 47, page 317 (issn: 1121-760X, eissn: 2038-8306, Copyright policy)
  • Publisher: PAGEPress Publications
<jats:p>Macrophage migration inhibitory factor (MIF) is a molecule known to regulate macrophage accumulation at sites of inflammation. To elucidate the role of MIF in progression of liver fibrosis, the immunohistochemical localization of MIF and macrophages in the liver were examined. Male Wistar rats received thioacetamide (TA) injections (200 mg/kg, i.p.) for 1 or 6 weeks. In biochemical and histological tests, it was confirmed that liver fibrosis was induced. In immunohistochemical analyses, the expression of MIF protein was seen in hepatocytes in the areas extending out from the central veins to the portal tracts. In particular, at 6 weeks, immunoreactivity ...
free text keywords: Biophysics, Cell Biology, Histology, Experimental pathology, Liver function tests, medicine.diagnostic_test, medicine, Exudate, medicine.symptom, Pathology, medicine.medical_specialty, Antibody, biology.protein, biology, Immunohistochemistry, Thioacetamide, chemistry.chemical_compound, chemistry, Anatomy, Macrophage migration inhibitory factor, Inflammation, Biology (General), QH301-705.5
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