Pectin-based colon-specific drug delivery

Article English OPEN
Shailendra Shukla ; Deepak Jain ; Kavita Verma ; Shiddarth Verma (2011)
  • Publisher: Wolters Kluwer Medknow Publications
  • Journal: Chronicles of Young Scientists (issn: 2229-5186, eissn: 0975-9212)
  • Related identifiers: doi: 10.4103/2229-5186.82978
  • Subject: Colon targeting | combination of polymer with other polymers | microflora | pectin | Therapeutics. Pharmacology | RM1-950

Colon-specific drug delivery have a great importance in the delivery of drugs for the treatment of local colonic, as well as systemic diseases like Crohn′s disease, ulcerative colitis, colorectal cancer, amoebiasis, asthma, arthritis and inflammation which can be achieved by targeted delivery of drug to colon. Specific systemic absorption in the colon gave interesting possibilities for the delivery of protein and peptides. It contains relatively less proteolytic enzyme activities in the colon compared to the upper gastrointestinal tract (GIT). Recommended treatments included the administration of anti-inflammatory drugs, chemotherapeutic agents and antibiotics which must be released in the colon. Pectin is a naturally occurring polysaccharide has in recent years gained increasingly in importance in advance drug delivery. It was employed in pharmaceutical industry, health promotion and treatment. Owing to its gelling properties it has been used potentially as a carrier for drug delivery to the GIT, such as matrix tablets, gel beads, film-coated dose form. This review will discuss the important chemistry and general properties of pectin, its gel formation mechanism properties and its uses in novel drug delivery to the colon.
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