publication . Article . Other literature type . 2018

Regional differences in brain glucose metabolism determined by imaging mass spectrometry

André Kleinridders; Heather A. Ferris; Michelle L. Reyzer; Michaela Rath; Marion Soto; M. Lisa Manier; Jeffrey M. Spraggins; Zhihong Yang; Robert Stanton; Richard M. Caprioli; ...
Open Access English
  • Published: 01 Jun 2018 Journal: Molecular Metabolism, volume 12, pages 113-121 (issn: 2212-8778, Copyright policy)
  • Publisher: Elsevier
  • Country: United States
Abstract
Objective Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregulation puts patients at increased risk for depression and Alzheimer's disease. In the present study, we aimed to determine how glucose is metabolized in different regions of the brain using imaging mass spectrometry (IMS). Methods To examine the relative abundance of glucose and other metabolites in the brain, mouse brain sections were subjected to imaging mass spectrometry at a resolution of 100 μm...
Persistent Identifiers
Subjects
free text keywords: Cell Biology, Molecular Biology, Brief Communication, Brain imaging, Glucose metabolism, ATP, Mass spectrometry, lcsh:Internal medicine, lcsh:RC31-1245, Carbohydrate metabolism, Metabolite, chemistry.chemical_compound, chemistry, Adenosine triphosphate, Hippocampal formation, Glycolysis, Hexose, chemistry.chemical_classification, White matter, medicine.anatomical_structure, medicine, Endocrinology, medicine.medical_specialty, Internal medicine, Pentose phosphate pathway
Funded by
NIH| Imaging Mass Spectrometry Research Resource at Vanderbilt University
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P41GM103391-05
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| INSULIN RECEPTOR STRUCTURE AND TURNOVER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK031036-11
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Diabetes and Endocrinology Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30DK036836-20
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| INSULIN RECEPTOR PHOSPHORYLATION AND INSULIN ACTION
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK033201-19
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Communities
Neuroinformatics
28 references, page 1 of 2

Ferris, H.A., Perry, R.J., Moreira, G.V., Shulman, G.I., Horton, J.D., Kahn, C.R.. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proc Natl Acad Sci U S A. 2017; 114 (5): 1189-1194 [OpenAIRE] [PubMed]

Jais, A., Solas, M., Backes, H., Chaurasia, B., Kleinridders, A., Theurich, S.. Myeloid-cell-Derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell. 2016; 165 (4): 882-895 [OpenAIRE] [PubMed]

Raichle, M.E., Gusnard, D.A.. Appraising the brain's energy budget. Proc Natl Acad Sci U S A. 2002; 99 (16): 10237-10239 [OpenAIRE] [PubMed]

McCrimmon, R.J., Ryan, C.M., Frier, B.M.. Diabetes and cognitive dysfunction. Lancet. 2012; 379 (9833): 2291-2299 [PubMed]

Hayes, J.D., McLellan, L.I.. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radical Research. 1999; 31 (4): 273-300 [PubMed]

Belanger, M., Allaman, I., Magistretti, P.J.. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metabolism. 2011; 14 (6): 724-738 [PubMed]

Howarth, C., Gleeson, P., Attwell, D.. Updated energy budgets for neural computation in the neocortex and cerebellum. Journal of Cerebral Blood Flow and Metabolism. 2012; 32 (7): 1222-1232 [OpenAIRE] [PubMed]

Herculano-Houzel, S., Mota, B., Lent, R.. Cellular scaling rules for rodent brains. Proc Natl Acad Sci U S A. 2006; 103 (32): 12138-12143 [OpenAIRE] [PubMed]

Sanchez-Abarca, L.I., Tabernero, A., Medina, J.M.. Oligodendrocytes use lactate as a source of energy and as a precursor of lipids. Glia. 2001; 36 (3): 321-329 [PubMed]

Amaral, A.I., Hadera, M.G., Tavares, J.M., Kotter, M.R., Sonnewald, U.. Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells. Glia. 2016; 64 (1): 21-34 [OpenAIRE] [PubMed]

Bouzier-Sore, A.K., Bolanos, J.P.. Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging. Frontiers in Aging Neuroscience. 2015; 7: 89 [OpenAIRE] [PubMed]

Tian, W.N., Pignatare, J.N., Stanton, R.C.. Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose-6-phosphate dehydrogenase from permeabilized cells. Journal of Biological Chemistry. 1994; 269 (20): 14798-14805 [PubMed]

Norris, J.L., Caprioli, R.M.. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chemical Reviews. 2013; 113 (4): 2309-2342 [OpenAIRE] [PubMed]

Franklin, K.B.J., Paxinos, G.. 2008

Funfschilling, U., Supplie, L.M., Mahad, D., Boretius, S., Saab, A.S., Edgar, J.. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature. 2012; 485 (7399): 517-521 [OpenAIRE] [PubMed]

28 references, page 1 of 2
Related research
Abstract
Objective Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregulation puts patients at increased risk for depression and Alzheimer's disease. In the present study, we aimed to determine how glucose is metabolized in different regions of the brain using imaging mass spectrometry (IMS). Methods To examine the relative abundance of glucose and other metabolites in the brain, mouse brain sections were subjected to imaging mass spectrometry at a resolution of 100 μm...
Persistent Identifiers
Subjects
free text keywords: Cell Biology, Molecular Biology, Brief Communication, Brain imaging, Glucose metabolism, ATP, Mass spectrometry, lcsh:Internal medicine, lcsh:RC31-1245, Carbohydrate metabolism, Metabolite, chemistry.chemical_compound, chemistry, Adenosine triphosphate, Hippocampal formation, Glycolysis, Hexose, chemistry.chemical_classification, White matter, medicine.anatomical_structure, medicine, Endocrinology, medicine.medical_specialty, Internal medicine, Pentose phosphate pathway
Funded by
NIH| Imaging Mass Spectrometry Research Resource at Vanderbilt University
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P41GM103391-05
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| INSULIN RECEPTOR STRUCTURE AND TURNOVER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK031036-11
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Diabetes and Endocrinology Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30DK036836-20
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| INSULIN RECEPTOR PHOSPHORYLATION AND INSULIN ACTION
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK033201-19
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Communities
Neuroinformatics
28 references, page 1 of 2

Ferris, H.A., Perry, R.J., Moreira, G.V., Shulman, G.I., Horton, J.D., Kahn, C.R.. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proc Natl Acad Sci U S A. 2017; 114 (5): 1189-1194 [OpenAIRE] [PubMed]

Jais, A., Solas, M., Backes, H., Chaurasia, B., Kleinridders, A., Theurich, S.. Myeloid-cell-Derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell. 2016; 165 (4): 882-895 [OpenAIRE] [PubMed]

Raichle, M.E., Gusnard, D.A.. Appraising the brain's energy budget. Proc Natl Acad Sci U S A. 2002; 99 (16): 10237-10239 [OpenAIRE] [PubMed]

McCrimmon, R.J., Ryan, C.M., Frier, B.M.. Diabetes and cognitive dysfunction. Lancet. 2012; 379 (9833): 2291-2299 [PubMed]

Hayes, J.D., McLellan, L.I.. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radical Research. 1999; 31 (4): 273-300 [PubMed]

Belanger, M., Allaman, I., Magistretti, P.J.. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metabolism. 2011; 14 (6): 724-738 [PubMed]

Howarth, C., Gleeson, P., Attwell, D.. Updated energy budgets for neural computation in the neocortex and cerebellum. Journal of Cerebral Blood Flow and Metabolism. 2012; 32 (7): 1222-1232 [OpenAIRE] [PubMed]

Herculano-Houzel, S., Mota, B., Lent, R.. Cellular scaling rules for rodent brains. Proc Natl Acad Sci U S A. 2006; 103 (32): 12138-12143 [OpenAIRE] [PubMed]

Sanchez-Abarca, L.I., Tabernero, A., Medina, J.M.. Oligodendrocytes use lactate as a source of energy and as a precursor of lipids. Glia. 2001; 36 (3): 321-329 [PubMed]

Amaral, A.I., Hadera, M.G., Tavares, J.M., Kotter, M.R., Sonnewald, U.. Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells. Glia. 2016; 64 (1): 21-34 [OpenAIRE] [PubMed]

Bouzier-Sore, A.K., Bolanos, J.P.. Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging. Frontiers in Aging Neuroscience. 2015; 7: 89 [OpenAIRE] [PubMed]

Tian, W.N., Pignatare, J.N., Stanton, R.C.. Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose-6-phosphate dehydrogenase from permeabilized cells. Journal of Biological Chemistry. 1994; 269 (20): 14798-14805 [PubMed]

Norris, J.L., Caprioli, R.M.. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chemical Reviews. 2013; 113 (4): 2309-2342 [OpenAIRE] [PubMed]

Franklin, K.B.J., Paxinos, G.. 2008

Funfschilling, U., Supplie, L.M., Mahad, D., Boretius, S., Saab, A.S., Edgar, J.. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature. 2012; 485 (7399): 517-521 [OpenAIRE] [PubMed]

28 references, page 1 of 2
Related research
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