Regional differences in brain glucose metabolism determined by imaging mass spectrometry

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Kleinridders, André; Ferris, Heather A.; Reyzer, Michelle L.; Rath, Michaela; Soto, Marion; Manier, M. Lisa; Spraggins, Jeffrey; Yang, Zhihong; Stanton, Robert C.; Caprioli, Richard M.; Kahn, C. Ronald;

Objective: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregul... View more