publication . Article . 2017

Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model

Atef Allam; Atef Allam; Sofia Casares; Kristina K. Peachman; Kristina K. Peachman; Mangala Rao; Ousman Jobe; Ousman Jobe; Jiae Kim; Jiae Kim; ...
Open Access English
  • Published: 01 Oct 2017 Journal: Frontiers in Immunology (issn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Humanized mice are emerging as an alternative model system to well-established non-human primate (NHP) models for studying human immunodeficiency virus (HIV)-1 biology and pathogenesis. Although both NHP and humanized mice have their own strengths and could never truly reflect the complex human immune system and biology, there are several advantages of using the humanized mice in terms of using primary HIV-1 for infection instead of simian immunodeficiency virus or chimera simian/HIV. Several different types of humanized mice have been developed with varying levels of reconstitution of human CD45+ cells. In this study, we utilized humanized Rag1KO.IL2RγcKO.NOD m...
Subjects
free text keywords: human immunodeficiency virus-1, human immunodeficiency virus vaginal transmission, humanized DRAG mouse, RNA, DNA, quantitative RT-PCR, Immunologic diseases. Allergy, RC581-607, Virology, Virus, Stem cell, Immunology, Biology, Lymph, Spleen, medicine.anatomical_structure, medicine, Immune system, Haematopoiesis, Bone marrow
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