publication . Article . 2012

Inhibitory Effects of Anthocyanins on Secretion of Helicobacter pylori CagA and VacA Toxins

Sa-Hyun Kim; Min Park; Hyunjun Woo; Nagendran Tharmalingam; Gyusang Lee; Ki-Jong Rhee; Yong Bin Eom; Sang Ik Han; Woo Duck Seo; Jong Bae Kim;
Open Access English
  • Published: 01 Nov 2012 Journal: International Journal of Medical Sciences (issn: 1449-1907, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
<p>Anthocyanins have been studied as potential antimicrobial agents against <i>Helicobacter pylori</i>. We investigated whether the biosynthesis and secretion of cytotoxin-associated protein A (CagA) and vacuolating cytotoxin A (VacA) could be suppressed by anthocyanin treatment <i>in vitro</i>. <i>H. pylori</i> reference strain 60190 (CagA<sup>+</sup>/VacA<sup>+</sup>) was used in this study to investigate the inhibitory effects of anthocyanins; cyanidin 3-O-glucoside (C3G), peonidin 3-O-glucoside (Peo3G), pelargonidin 3-O-glucoside (Pel3G), and malvidin 3-O-glucoside (M3G) on expression and secretion of <i>H. pylori</i> toxins. Anthocyanins were added to bacte...
Subjects
Medical Subject Headings: bacterial infections and mycosesbacteriadigestive system diseases
free text keywords: Medicine, R, Short Research Communication, Helicobacter pylori, CagA, VacA, SecA, anthocyanin, cyanidin 3-O-glucoside., General Medicine, Pelargonidin, chemistry.chemical_compound, chemistry, In vitro, Protein A, biology.protein, biology, biology.organism_classification, Microbiology, Molecular biology, Toxin, medicine.disease_cause, Secretion, Blot
Related Organizations
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