publication . Article . 2017

Corvitin restores metallothionein and glial fibrillary acidic protein levels in rat brain affected by pituitrin-izadrin

H. N. Shiyntum; O. O. Dovban; Y. P. Kovalchuk; T. Ya. Yaroshenko; G. A. Ushakova;
Open Access
  • Published: 01 Jun 2017 Journal: The Ukrainian Biochemical Journal, volume 89, pages 36-45 (issn: 2409-4943, Copyright policy)
  • Publisher: Co. Ltd. Ukrinformnauka
Abstract
In this research, we investigated the effect of pituitrin-izadrin induced injury on the levels of metallothionein (MT) and soluble and filament forms of glial fibrillary acidic protein (GFAP) in the hippocampus, cerebellum, thalamus, and the cerebral cortex, and examined the effect of corvitin on the brain under the noted changes. Our results showed oppositely directed changes – a decrease in the level of MT and an increase in GFAP in the rat brain, with a tendency to astrogliosis development, under the influence of systemic deficiencies in myocardial function. The use of corvitin at a dose of 42 mg/kg for five days after a cardiac attack caused by pituitary-iza...
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Subjects
Medical Subject Headings: nervous system
free text keywords: Biochemistry, Rat brain, Metallothionein, Molecular biology, Glial fibrillary acidic protein, biology.protein, biology, Chemistry, GFAP stain, Pituitrin, lcsh:Biochemistry, lcsh:QD415-436
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