publication . Article . 2003

Inhibition by Zn2+ of A-form Monoamine Oxidase in Monkey Brain Mitochondria

Toru Egashira; Fusako Takayama; Kumiko Sakai;
Open Access English
  • Published: 01 Jan 2003 Journal: Journal of Pharmacological Sciences (issn: 1347-8613, Copyright policy)
  • Publisher: Elsevier
Abstract
Abstract The effects of ZnSO 4 on mitochondrial monoamine oxidase (MAO) activity in monkey brain were compared with those in rat and rabbit, in vitro. After preincubation at 25°C for 20 min with 1 μM ZnSO 4 , MAO-A activity in monkey brain was about 50% using serotonin (5-HT) as a substrate, and the inhibition was proportional to the concentration of ZnSO 4 . However, ZnSO 4 had no effect on MAO-B activity in monkey brain using β-phenylethylamine (β-PEA) as a substrate. The inhibition by ZnSO 4 of MAO-A activity was competitive and reversible. CdSO 4 also inhibits MAO-A, but not MAO-B in monkey brain mitochondria. ZnSO 4 did not inhibit either MAO-A or MAO-B act...
Subjects
free text keywords: Therapeutics. Pharmacology, RM1-950, Biochemistry, Monoamine oxidase, Substrate (chemistry), Catecholamine, medicine.drug, medicine, In vitro, Serotonin, Brain mitochondria, Animal species, Biology
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