B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade

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Martin, Rebecca K. ; Damle, Sheela R. ; Valentine, Yolander A. ; Zellner, Matthew P. ; James, Briana N. ; Lownik, Joseph C. ; Luker, Andrea J. ; Davis, Elijah H. ; DeMeules, Martha M. ; Khandjian, Laura M. ; Finkelman, Fred D. ; Urban, Joseph F. ; Conrad, Daniel H. (2018)
  • Publisher: Elsevier
  • Journal: Cell reports, volume 22, issue 7, pages 1,824-1,834 (issn: 2211-1247, eissn: 2211-1247)
  • Related identifiers: doi: 10.1016/j.celrep.2018.01.048, pmc: PMC5832064
  • Subject: B1 cells | histamine | IgE | B2 cells | mast cells | N. brasiliensis | Article | QH301-705.5 | IL-25 | helminth | Biology (General) | Th2
    mesheuropmc: parasitic diseases

SUMMARY Helminth infection is known for generating large amounts of poly-specific IgE. Here we demonstrate that innate-like B1 cells are responsible for this IgE production during infection with the nematode parasites Nippostrongylus brasiliensis and Heligmosomoides pol... View more
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