B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade

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Martin, Rebecca K.; Damle, Sheela R.; Valentine, Yolander A.; Zellner, Matthew P.; James, Briana N.; Lownik, Joseph C.; Luker, Andrea J.; Davis, Elijah H.; DeMeules, Martha M.; Khandjian, Laura M.; Finkelman, Fred D.; Urban, Joseph F.; Conrad, Daniel H.;

SUMMARY Helminth infection is known for generating large amounts of poly-specific IgE. Here we demonstrate that innate-like B1 cells are responsible for this IgE production during infection with the nematode parasites Nippostrongylus brasiliensis and Heligmosomoides pol... View more
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