publication . Article . Other literature type . 2018

B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade

Daniel H. Conrad; Laura M. Khandjian; Sheela R. Damle; Joseph C. Lownik; Matthew P. Zellner; Joseph F. Urban; Fred D. Finkelman; Fred D. Finkelman; Yolander A. Valentine; Martha M. DeMeules; ...
Open Access
  • Published: 01 Feb 2018 Journal: Cell Reports, volume 22, pages 1,824-1,834 (issn: 2211-1247, Copyright policy)
  • Publisher: Elsevier BV
Abstract
In Brief Martin et al. show that B1 cell IgE is induced during Th2 helminth infections by IL-25. This B1 cell IgE blocks parasite clearance through inhibition of mucosal mast cell activation by B2 cell IgE.
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: General Biochemistry, Genetics and Molecular Biology, Article, helminth, B1 cells, B2 cells, mast cells, Th2, N. brasiliensis, Biology (General), QH301-705.5, Heligmosomoides polygyrus, biology.organism_classification, biology, Immunoglobulin E, biology.protein, Histamine, chemistry.chemical_compound, chemistry, B-1 cell, Secretion, Immunology, Mast cell, medicine.anatomical_structure, medicine, Nippostrongylus brasiliensis, Cell
Funded by
NIH| Helminth induced B1 IgE is protective against allergic disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1F32AI124502-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| CORE--PLANNING AND EVALUATION
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30CA016059-20
  • Funding stream: NATIONAL CANCER INSTITUTE
51 references, page 1 of 4

Ahmed, A., and Koma, M.K. (2015). Interleukin-33 triggers B1 cell expansion and its release of monocyte/macrophage chemoattractants and growth factors. Scand. J. Immunol. 82, 118-124.

Baniyash, M., Kehry, M., and Eshhar, Z. (1988). Anti-IgE monoclonal antibodies directed at the Fc epsilon receptor binding site. Mol. Immunol. 25, 705-711.

Baumgarth, N., Tung, J.W., and Herzenberg, L.A. (2005). Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin. Immunopathol. 26, 347-362. [OpenAIRE]

Bazaral, M., Orgel, H.A., and Hamburger, R.N. (1973). The influence of serum IgE levels of selected recipients, including patients with allergy, helminthiasis and tuberculosis, on the apparent P-K titre of a reaginic serum. Clin. Exp. Immunol. 14, 117-125. [OpenAIRE]

Brandt, E.B., Strait, R.T., Hershko, D., Wang, Q., Muntel, E.E., Scribner, T.A., Zimmermann, N., Finkelman, F.D., and Rothenberg, M.E. (2003). Mast cells are required for experimental oral allergen-induced diarrhea. J. Clin. Invest. 112, 1666-1677.

Camberis, M., Le Gros, G., and Urban, J., Jr. (2003). Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr. Protoc. Immunol. Chapter 19, 12. [OpenAIRE]

de Silva, N.R., Brooker, S., Hotez, P.J., Montresor, A., Engels, D., and Savioli, L. (2003). Soil-transmitted helminth infections: updating the global picture. Trends Parasitol. 19, 547-551. [OpenAIRE]

Erickson, L.D., Foy, T.M., and Waldschmidt, T.J. (2001). Murine B1 B cells require IL-5 for optimal T cell-dependent activation. J. Immunol. 166, 1531- 1539. [OpenAIRE]

Evans, H., Killoran, K.E., and Mitre, E. (2014). Measuring local anaphylaxis in mice. J. Vis. Exp. (92), e52005. [OpenAIRE]

Finkelman, F.D., Shea-Donohue, T., Morris, S.C., Gildea, L., Strait, R., Madden, K.B., Schopf, L., and Urban, J.F., Jr. (2004). Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol. Rev. 201, 139-155. [OpenAIRE]

Fort, M.M., Cheung, J., Yen, D., Li, J., Zurawski, S.M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., et al. (2001). IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15, 985-995.

Gerbe, F., Sidot, E., Smyth, D.J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., et al. (2016). Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529, 226-230.

Gibb, D.R., Saleem, S.J., Kang, D.-J., Subler, M.A., and Conrad, D.H. (2011). ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch. J. Immunol. 186, 4244-4252.

Gurish, M.F., Bryce, P.J., Tao, H., Kisselgof, A.B., Thornton, E.M., Miller, H.R., Friend, D.S., and Oettgen, H.C. (2004). IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J. Immunol. 172, 1139-1145.

Hepworth, M.R., Maurer, M., and Hartmann, S. (2012). Regulation of type 2 immunity to helminths by mast cells. Gut Microbes 3, 476-481.

51 references, page 1 of 4
Abstract
In Brief Martin et al. show that B1 cell IgE is induced during Th2 helminth infections by IL-25. This B1 cell IgE blocks parasite clearance through inhibition of mucosal mast cell activation by B2 cell IgE.
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: General Biochemistry, Genetics and Molecular Biology, Article, helminth, B1 cells, B2 cells, mast cells, Th2, N. brasiliensis, Biology (General), QH301-705.5, Heligmosomoides polygyrus, biology.organism_classification, biology, Immunoglobulin E, biology.protein, Histamine, chemistry.chemical_compound, chemistry, B-1 cell, Secretion, Immunology, Mast cell, medicine.anatomical_structure, medicine, Nippostrongylus brasiliensis, Cell
Funded by
NIH| Helminth induced B1 IgE is protective against allergic disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1F32AI124502-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| CORE--PLANNING AND EVALUATION
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30CA016059-20
  • Funding stream: NATIONAL CANCER INSTITUTE
51 references, page 1 of 4

Ahmed, A., and Koma, M.K. (2015). Interleukin-33 triggers B1 cell expansion and its release of monocyte/macrophage chemoattractants and growth factors. Scand. J. Immunol. 82, 118-124.

Baniyash, M., Kehry, M., and Eshhar, Z. (1988). Anti-IgE monoclonal antibodies directed at the Fc epsilon receptor binding site. Mol. Immunol. 25, 705-711.

Baumgarth, N., Tung, J.W., and Herzenberg, L.A. (2005). Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin. Immunopathol. 26, 347-362. [OpenAIRE]

Bazaral, M., Orgel, H.A., and Hamburger, R.N. (1973). The influence of serum IgE levels of selected recipients, including patients with allergy, helminthiasis and tuberculosis, on the apparent P-K titre of a reaginic serum. Clin. Exp. Immunol. 14, 117-125. [OpenAIRE]

Brandt, E.B., Strait, R.T., Hershko, D., Wang, Q., Muntel, E.E., Scribner, T.A., Zimmermann, N., Finkelman, F.D., and Rothenberg, M.E. (2003). Mast cells are required for experimental oral allergen-induced diarrhea. J. Clin. Invest. 112, 1666-1677.

Camberis, M., Le Gros, G., and Urban, J., Jr. (2003). Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr. Protoc. Immunol. Chapter 19, 12. [OpenAIRE]

de Silva, N.R., Brooker, S., Hotez, P.J., Montresor, A., Engels, D., and Savioli, L. (2003). Soil-transmitted helminth infections: updating the global picture. Trends Parasitol. 19, 547-551. [OpenAIRE]

Erickson, L.D., Foy, T.M., and Waldschmidt, T.J. (2001). Murine B1 B cells require IL-5 for optimal T cell-dependent activation. J. Immunol. 166, 1531- 1539. [OpenAIRE]

Evans, H., Killoran, K.E., and Mitre, E. (2014). Measuring local anaphylaxis in mice. J. Vis. Exp. (92), e52005. [OpenAIRE]

Finkelman, F.D., Shea-Donohue, T., Morris, S.C., Gildea, L., Strait, R., Madden, K.B., Schopf, L., and Urban, J.F., Jr. (2004). Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol. Rev. 201, 139-155. [OpenAIRE]

Fort, M.M., Cheung, J., Yen, D., Li, J., Zurawski, S.M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., et al. (2001). IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15, 985-995.

Gerbe, F., Sidot, E., Smyth, D.J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., et al. (2016). Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529, 226-230.

Gibb, D.R., Saleem, S.J., Kang, D.-J., Subler, M.A., and Conrad, D.H. (2011). ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch. J. Immunol. 186, 4244-4252.

Gurish, M.F., Bryce, P.J., Tao, H., Kisselgof, A.B., Thornton, E.M., Miller, H.R., Friend, D.S., and Oettgen, H.C. (2004). IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J. Immunol. 172, 1139-1145.

Hepworth, M.R., Maurer, M., and Hartmann, S. (2012). Regulation of type 2 immunity to helminths by mast cells. Gut Microbes 3, 476-481.

51 references, page 1 of 4
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