publication . Article . 2017

Polyclonal antibodies against recombinant dengue virus NS3 protein

Jacqueline Chaparro-Olaya; María Angélica Calderon; Myriam L. Velandia; Jaime E. Castellanos; Liliana Morales;
Open Access Spanish
  • Published: 24 Jan 2017
  • Publisher: Instituto Nacional de Salud
Abstract
Resumen Introducción: El dengue es una enfermedad causada por uno de los cuatro serotipos del virus del dengue (DENV) y es endémica en, aproximadamente, 130 países. Su incidencia ha aumentado notablemente en las últimas décadas, así como la frecuencia y la magnitud de los brotes. A pesar de los esfuerzos, no existen tratamientos profilácticos ni terapéuticos contra la enfermedad y, en ese contexto, el estudio de los procesos que gobiernan el ciclo de infección del DENV es esencial para desarrollar vacunas o terapias antivirales. Una de las moléculas del DENV más prometedoras es la proteína no estructural 3 (NS3), la cual es indispensable para la replicación vira...
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doi: 10.7705/biomedica.v37i1.3249
Subjects
Medical Subject Headings: virusesbiochemical phenomena, metabolism, and nutritionvirus diseases
free text keywords: virus del dengue, proteínas recombinantes, inmunoprecipitación, producción de anticuerpos, Western blotting, Dengue virus, recombinant protein, immunofluorescence, immunoprecipitation, antibody production, blotting, Western, Medicine, R, Arctic medicine. Tropical medicine, RC955-962, General Biochemistry, Genetics and Molecular Biology, General Medicine, Western blot, medicine.diagnostic_test, Virology, Dengue fever, medicine.disease, Viral replication, Virus, medicine.disease_cause, Antibody, biology.protein, biology, Viral protein, NS3
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