publication . Article . 2017

Autoinmune encephalitis associated to antibodies against the receptor N-methyl-D-aspartate: report of two cases

Rommy Olivieri; Yasmin Sánchez; Johan Ortiz; Jhon Medina; Julián Mojica; José Bustos;
Open Access Spanish
  • Published: 01 Apr 2017
  • Publisher: Instituto Nacional de Salud
Abstract
Resumen La encefalitis asociada a anticuerpos contra receptores N-metil-D-aspartato es un síndrome neurológico que se presenta más comúnmente en mujeres jóvenes y frecuentemente se asocia al teratoma de ovario. Se caracteriza por un cuadro clínico agudo con síntomas generales inespecíficos que evoluciona hacia deterioro neurológico, psicosis y convulsiones; en su etapa más avanzada, se asocia con movimientos anormales y disautonomía. Se reportan dos casos en mujeres de 23 y 12 años. Dada su baja incidencia, se explica el proceso clínico que llevó a su diagnóstico y las opciones de tratamiento empleadas. Abstract Anti-N-methyl-D-aspartate receptor encephalitis is...
Subjects
free text keywords: encefalitis, receptores de glutamato, N-metilaspartato, autoinmunidad, inmunoterapia, anticuerpos, Encephalitis, receptors, glutamate, N-methylaspartate, autoimmunity, immunotherapy, antibodies, General Biochemistry, Genetics and Molecular Biology, General Medicine, R, Arctic medicine. Tropical medicine, RC955-962, Receptor, D aspartate, medicine.disease, medicine, Chemistry, Virology, Antibody, biology.protein, biology
22 references, page 1 of 2

1. Tsien JZ. Building a brainier mouse. Sci Am. 2000;282:62-8. http://dx.doi.org/10.1038/scientificamerican0400-62

2. Tüzün E, Dalmau J. Limbic encephalitis and variants: Classification, diagnosis and treatment. Neurologist. 2007;13: 261-71. http://dx.doi.org/10.1097/NRL.0b013e31813e34a5 [OpenAIRE]

3. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies. Lancet Neurol. 2008; 7:1091-8. http://dx.doi.org/10.1016/S1474- 4422(08)70224-2

4. Florance NR, Davis RL, Lam C, Szperka C, Zhou L, Ahmad S, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009;66:11-8. http://dx.doi.org/10.1002/ana.21756

5. Dalmau J, Tüzün E, Wu H, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25-36. http://dx.doi.org/10.1002/ana.21050 [OpenAIRE]

6. Day GS, High SM, Cot B, Tang-Wai DF. Anti-NMDA-receptor encephalitis: Case report and literature review of an underrecognized condition. J Gen Intern Med. 2011;26:811-6. http://dx.doi.org/10.1007/s11606-011-1641-9

7. Miya K, Takahashi Y, Mori H. Anti-NMDAR autoimmune encephalitis. Brain Dev. 2014;36:645-52. http://dx.doi.org/10. 1016/j.braindev.2013.10.005

8. Suárez DV, Rojas JP, Castillo GE, Díaz E, Montero FJ. Encefalitis por anticuerpos contra el receptor N-metil D-aspartato (NMDAR) en pediatría. Reporte de caso y revisión de la literatura. Acta Neurológica Colombiana. 2014;30:193-9.

9. De Broucker T, Martínez-Almoyna L. Anti-NMDA-receptor encephalitis. Med Mal Infect. 2010;40:1-5. http://dx.doi. org/10.1016/j.medmal.2009.10.013

10. Iizuka T, Sakai F, Ide T, Monzen T, Yoshii S, Iigaya M, et al. Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal. Neurology. 2008;70:504- 11. http://dx.doi.org/10.1212/01.wnl.0000278388.90370.c3

11. Sansing LH, Tüzün E, Ko MW, Baccon J, Lynch DR, Dalmau J. A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol. 2007;3:291-6. http://dx.doi.org/10.1038/ncpneuro0493

12. Kruse JL, Jeffrey JK, Davis MC, Dearlove J, IsHak WW, Brooks JO. Anti-N-methyl-D-aspartate receptor encephalitis: A targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management. Ann Clin Psychiatry. 2014;26:111-9.

13. Johnson N, Henry C, Fessler AJ, Dalmau J. Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus. Neurology. 2010;75:1480-2. http://dx.doi. org/10.1212/WNL.0b013e3181f8831a

14. Lazar-Molnar E, Tebo AE. Autoimmune NMDA receptor encephalitis. Clin Chim Acta. 2015;438:90-7. http://dx.doi. org/10.1016/j.cca.2014.08.010

15. Jones KC, Benseler SM, Moharir M. Anti-NMDA receptor encephalitis. Neuroimaging Clin. 2013;23:309-20. http://dx. doi.org/10.1016/j.nic.2012.12.009

22 references, page 1 of 2
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