publication . Article . 2018

Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα

Ying Sun; Ying Sun; Yu-jun Tan; Yu-jun Tan; Zhan-zhao Lu; Zhan-zhao Lu; Bing-bing Li; Bing-bing Li; Cheng-hong Sun; Cheng-hong Sun; ...
Open Access English
  • Published: 01 Mar 2018 Journal: Frontiers in Pharmacology (issn: 1663-9812, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Burdock (Arctium lappa) is a popular vegetable in China and Japan that is consumed for its general health benefits. The principal active component of burdock is arctigenin, which shows a range of bioactivities in vivo and in vitro. Here, we investigated the potential anti-tumor effects of arctigenin using two human hepatocellular carcinoma (HCC) cell lines, HepG2 and Hep3B, and sought to elucidate its potential mechanisms of action. Our results showed that arctigenin treatment inhibited cell growth in both HepG2 and Hep3B cell lines (IC50 of 4.74 nM for HepG2 cells, and of 59.27 nM for Hep3B cells). In addition, migration, invasion, and colony formation by HepG2...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: arctigenin, C/EBPα, PPARα, gankyrin, hepatocellular carcinoma, Therapeutics. Pharmacology, RM1-950, Pharmacology (medical), Pharmacology, Original Research, Chemistry, Mechanism of action, medicine.symptom, medicine, Molecular biology, Cell growth, Carcinogenesis, medicine.disease_cause, biology.protein, biology, Luciferase, Cell culture, In vitro, chemistry.chemical_compound
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