publication . Article . 2015

Peripheral nerve injury induces glial activation in primary motor cortex

Julieta Troncoso; Julieta Troncoso; Efraín Buriticá; Efraín Buriticá;
Open Access English
  • Published: 01 Feb 2015 Journal: Frontiers in Cellular Neuroscience, volume 9 (issn: 1662-5102, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Preliminary evidence suggests that peripheral facial nerve injuries are associated with sensorimotor cortex reorganization. We have characterized facial nerve lesion-induced structural changes in primary motor cortex layer 5 pyramidal neurons and their relationship with glial cell density using a rodent facial paralysis model. First, we used adult transgenic mice expressing green fluorescent protein in microglia and yellow fluorescent protein in pyramidal neurons which were subjected to either unilateral lesion of the facial nerve or sham surgery. Two-photon excitation microscopy was then used for evaluating both layer 5 pyramidal neurons and microglia in vibris...
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Medical Subject Headings: nervous system
free text keywords: layer 5 pyramidal cells, dendritic remodeling, Facial nerve lesion, Vibrissal primary motor cortex, Microglia activation; astrogliosis, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571
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