publication . Article . Other literature type . 2018

Profiling Prostate Cancer Therapeutic Resistance.

Cameron A. Wade; Natasha Kyprianou;
Open Access English
  • Published: 19 Mar 2018 Journal: International Journal of Molecular Sciences, volume 19, issue 3 (eissn: 1422-0067, Copyright policy)
  • Publisher: MDPI
Abstract
The major challenge in the treatment of patients with advanced lethal prostate cancer is therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy. Overriding this resistance requires understanding of the driving mechanisms of the tumor microenvironment, not just the androgen receptor (AR)-signaling cascade, that facilitate therapeutic resistance in order to identify new drug targets. The tumor microenvironment enables key signaling pathways promoting cancer cell survival and invasion via resistance to anoikis. In particular, the process of epithelial-mesenchymal-transition (EMT), directed by transforming growth factor-β (TGF-β), confers stem...
Subjects
free text keywords: Review, epithelial plasticity, androgen receptor, tumor landscape, metabolic changes, Biology (General), QH301-705.5, Chemistry, QD1-999, Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Spectroscopy, Molecular Biology, Catalysis, General Medicine, Computer Science Applications
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