Profiling Prostate Cancer Therapeutic Resistance

Article English OPEN
Cameron A. Wade ; Natasha Kyprianou (2018)
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences, volume 19, issue 3 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: doi: 10.3390/ijms19030904, pmc: PMC5877765
  • Subject: metabolic changes | Chemistry | androgen receptor | Review | QD1-999 | epithelial plasticity | Biology (General) | tumor landscape | QH301-705.5

The major challenge in the treatment of patients with advanced lethal prostate cancer is therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy. Overriding this resistance requires understanding of the driving mechanisms of the tumor microenvironm... View more
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