publication . Article . 2018

Dengue, zika, chikungunya and the development of vaccines

Isabel N. Kantor;
Open Access English
  • Published: 01 Jan 2018 Journal: Medicina (Buenos Aires), volume 78, issue 1, pages 23-28 (issn: 0025-7680, eissn: 1669-9106, Copyright policy)
  • Publisher: Fundación Revista Medicina
Abstract
Dengue (DENV), zika (ZIKV) and chikungunya (CHIKV), three arbovirosis transmitted by Aedes mosquitoes, have spread in recent decades in humid tropical and subtropical zones. Dengue is epidemic in subtropical areas of Argentina. DENV infection confers lasting immunity against the infecting serotype but increases the risk of serious disease upon reinfection by any of the other three. The recombinant tetravalent vaccine Dengvaxia® prevents severe dengue and hospitalization in seropositive subjects. In 2017, Dengvaxia was approved in Argentina, for ages 9 to 45, but is not included in the national vaccination calendar. Two other vaccines are in Phase III evaluation:...
Subjects
Medical Subject Headings: virus diseases
free text keywords: arbovirus, dengue, zika, chikungunya, vaccine development, Argentina, lcsh:Medicine, lcsh:R, lcsh:Immunologic diseases. Allergy, lcsh:RC581-607, lcsh:Infectious and parasitic diseases, lcsh:RC109-216
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