publication . Article . 2009

Study of morphological alterations of the adrenal glands in the neoplastic cachexia
Estudo das alterações morfológicas da glândula adrenal na caquexia neoplásica

Tânia Longo Mazzuco; Karina Garcia Cotrim; Alexandre Yukio Saito; Marcelo Abbá Macioszek; Eveline Aparecida Isquierdo Fonseca;
Open Access English
  • Published: 01 Jan 2009 Journal: Semina : Ciências Biológicas e da Saúde, volume 30, issue 2, pages 163-174 (issn: 1676-5435, eissn: 1679-0367, Copyright policy)
  • Publisher: Universidade Estadual de Londrina
Abstract
Advanced cancer occurs with nutritional and metabolic alterations that characterize neoplastic cachexia. When homeostasis is compromised, the adrenal glands have a fundamental role in the neuroendocrine response. Our purpose in this research was to study morphological alterations of the adrenal glands in the development of cancer associated to cachexia. Cachexia experimental model induced by Walker 256 tumor in Wistar rats, was used. Animals were sacrificed 12 days after tumor cells inoculation and adrenal glands removal for histopathologic analysis by means of hematoxylin and eosin stain. Nutritional parameters, cachexia index and adrenal glands weight, were ev...
Subjects
free text keywords: Carcinoma 256 de Walker, Caquexia, Glândulas Supra-Renais, Eixo HPA, lcsh:Medicine (General), lcsh:R5-920, lcsh:Biology (General), lcsh:QH301-705.5
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