Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets

Article English OPEN
Lotta K. Veistinen; Tuija Mustonen; Tuija Mustonen; Md. Rakibul Hasan; Maarit Takatalo; Yukiho Kobayashi; Yukiho Kobayashi; Dörthe A. Kesper; Andrea Vortkamp; David P. Rice; David P. Rice; (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Physiology (issn: 1664-042X)
  • Related identifiers: doi: 10.3389/fphys.2017.01036, doi: 10.3389/fphys.2017.01036/full
  • Subject: calvarial development | QP1-981 | cell differentiation | craniosynostosis | Physiology | osteoblast | hedgehog signaling pathway
    mesheuropmc: body regions | embryonic structures | musculoskeletal system | musculoskeletal diseases | stomatognathic system

Loss-of-function mutations in GLI3 and IHH cause craniosynostosis and reduced osteogenesis, respectively. In this study, we show that Ihh ligand, the receptor Ptch1 and Gli transcription factors are differentially expressed in embryonic mouse calvaria osteogenic condens... View more
Share - Bookmark