publication . Article . 2016

Formulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique

Fatemeh Pourhashem; Mohammad Reza Avadi;
Open Access English
  • Published: 01 Jun 2016 Journal: Journal of Pharmaceutical and Health Sciences, volume 4, issue 1, pages 35-41 (issn: 2228-6780, eissn: 2322-4738, Copyright policy)
  • Publisher: Islamic Azad University
Abstract
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidem tartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicating it a candidate for the extended release formulation. Our investigation relates to development of extended drug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4M) as release retardant, polyvinyl pyrrolidone (PVP k30) as binder and Magnesium Stearate using Factorial design. In vitro release study of matrix tablets was carried out in 0.01N HCl for 2 hours. All prepared matrix tablets were evaluated for physicochemical evaluation...
Subjects
free text keywords: Zolpidem tartrate, Wet granulation, Hydroxy propyl methyl cellulose (K4M), Factorial design, ICH guideline, lcsh:Pharmacy and materia medica, lcsh:RS1-441, lcsh:Public aspects of medicine, lcsh:RA1-1270

Aulton, ME. Preformulation. In: Pharmaceutics The Design and Manufacture of Medicines. Edinburgh: Chuchill Livingstone, 2007: 546-7.

Chein, YW. Novel drug delivery systems. 2nd ed. Amesterdam: Marcel Dekker, 1992: 1-39.

Goodman LS, Gilman A. Goodman and Gilman's the pharmaceutical Basis of therapeutics. 9th ed. New York, 1966: 98-128.

Karwa, P, Kasture, PV. Formulation and in vitro evaluation of bilayer tablets of Zolpidem tartrate for biphasic drug release. Int J Pharm Tech Res 2011; 3(4): 1919-29.

Kirkwood, C, Neill, J, Breden, E. Zolpidem modifiedrelease in insomnia. Neuropsychiatric disease and treatment. Neuropsychiatr Dis Treat 2007; 3(5): 521-6.

United States Pharmacopeia. 35th ed. Easton: U.S. pharmacopeial convention Inc 2012: 1934, 1935, 2734, 2735, 2736.

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