publication . Article . 2016

Formulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique

Fatemeh Pourhashem; Mohammad Reza Avadi;
Open Access English
  • Published: 01 Jun 2016 Journal: Journal of Pharmaceutical and Health Sciences, volume 4, issue 1, pages 35-41 (issn: 2228-6780, eissn: 2322-4738, Copyright policy)
  • Publisher: Islamic Azad University
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidem tartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicating it a candidate for the extended release formulation. Our investigation relates to development of extended drug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4M) as release retardant, polyvinyl pyrrolidone (PVP k30) as binder and Magnesium Stearate using Factorial design. In vitro release study of matrix tablets was carried out in 0.01N HCl for 2 hours. All prepared matrix tablets were evaluated for physicochemical evaluation...
free text keywords: Zolpidem tartrate, Wet granulation, Hydroxy propyl methyl cellulose (K4M), Factorial design, ICH guideline, lcsh:Pharmacy and materia medica, lcsh:RS1-441, lcsh:Public aspects of medicine, lcsh:RA1-1270

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