publication . Article . 2016

Study efficacy of new model of derivative clonazepam on hypnotic, sedative, blood hematology and evaluation reproductive function in male mice

Adnan M. Jassim; Abbas G. Hamad; Mohammed Abed; Raad Saad;
Open Access English
  • Published: 01 Dec 2016 Journal: Journal of Contemporary Medical Sciences (issn: 2413-0516, Copyright policy)
  • Publisher: Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press
Abstract
Objectives This study includes the investigation of hypnotic and sedative effect of new generation agent synthesis from parent clonazepam and evaluates adverse effect on the reproductive system and an attempt to improve hypnotic effect and lower toxicity. Methods Sixteen male mice were randomly divided into four groups. The first day of treatment with single dose of 50 mg/kg intraperitoneal (IP) hypnotic effect then analgesic state was recorded in the 4th day of first week only after given 30 mg/kg orally, and then the experiment was persistent for 4 weeks to evaluate reproductive activity. Result The effect of diazepam on biochemical blood parameters showed tha...
Subjects
free text keywords: clonazepam, hypnotic, availability, abnormality, Medicine (General), R5-920, Reproductive function, Anesthesia, Hematology, medicine.medical_specialty, medicine, Sedative, medicine.drug_class, business.industry, business, Clonazepam, medicine.drug, Pharmacology, Hypnotic, Internal medicine
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2016

Study efficacy of new model of derivative clonazepam on hypnotic, sedative, blood hematology and evaluation reproductive function in male mice

Adnan M. Jassim; Abbas G. Hamad; Mohammed Abed; Raad Saad;