publication . Article . 1998

Blockade of Cd40-Cd154 Interferes with Human T cell Engraftment in Scid Mice

Teresa M. Foy; Melissa Mcilraith; Sally R. Masters; Jonathan J. Dunn; Aldo A. Rossini; Leonard D. Shultz; Ruth Ann M. Hesselton; Eric J. Wagar; Peter E. Lipsky; Randolph J. Noelle; ...
Open Access English
  • Published: 01 Jan 1998 Journal: Cell Transplantation (issn: 0963-6897, eissn: 1555-3892, Copyright policy)
  • Publisher: SAGE Publishing
Abstract
Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion o...
Subjects
mesheuropmc: chemical and pharmacologic phenomena
free text keywords: R, Medicine
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