publication . Article . 2013

In vivo studies on detoxifying actions of aqueous bark extract of Prosopis cineraria against crude venom from Indian cobra (Naja naja)

Thirunavukkarasu Sivaraman; Sivarathri Siva Rajesh; Veerayan Elango;
Open Access English
  • Published: 01 Nov 2013 Journal: Bangladesh Journal of Pharmacology (issn: 1991-0088, Copyright policy)
  • Publisher: Bangladesh Pharmacological Society
Detoxification effect of aqueous, methanol and petroleum ether extracts of medicinal plants such as Aristolochia bracteolata, Mucuna pruriens, Prosopis cineraria and Rauvolfia tetraphylla was systematically screened against lethality of crude venom of Naja naja using Swiss albino mice as animal models. We have herein demonstrated that aqueous bark extract of P. cineraria has substantial anti-venom potential vis-a-vis other extracts used in the present study. The aqueous extract at the dose of 14 mg/kg b.w. was able to almost completely neutralize the lethal activity of 3LD 50 (1.12 mg/kg b.w.) of the cobra venom and the extract did not cause any types of adverse...
Medical Subject Headings: complex mixtures
free text keywords: Antidote, Antagonists, Folklore, In vivo, Naja naja., Therapeutics. Pharmacology, RM1-950, Naja naja, Pharmacology
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