publication . Article . 2013

NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders

Mauro Ceccanti; Sara De Nicolò; Rosanna Mancinelli; George Chaldakov; Valentina Carito; Marco Ceccanti; Giovanni Laviola; Paola Tirassa; Marco Fiore;
Open Access English
  • Published: 01 Dec 2013 Journal: Annali dell'Istituto Superiore di Sanità (issn: 0021-2571, Copyright policy)
  • Publisher: Istituto Superiore di Sanità
Abstract
OBJECTIVES: Fetal Alcohol Spectrum Disorders (FASD) due to prenatal ethanol consumption may induce long-lasting changes to the newborns affecting also the endocrine system and the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) signaling. Thus the aim of this study was to investigate in the thyroid, testis and adrenal glands of a FASD mouse model the long-lasting effects of ethanol exposure during pregnancy and lactation on NGF and BDNF and their main receptors, TrkA and TrkB, including their phosphorylated patterns. METHODS: We used aged male CD-1 mice early exposed to ethanol solution or red wine at same ethanol concentration (11% vol). ...
Subjects
Medical Subject Headings: nervous system
free text keywords: nerve growth factor, brain derived, neurotrophic factor, fetal alcohol spectrum, disorders, FASD, Public aspects of medicine, RA1-1270
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