PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression

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Grazia eMaugeri ; Agata Grazia eD'Amico ; Agata Grazia eD'Amico ; Rita eReitano ; Gaetano eMagro ; Sebastiano eCavallaro ; Salvatore eSalomone ; Velia eD'Agata (2016)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Pharmacology (issn: 1663-9812)
  • Related identifiers: doi: 10.3389/fphar.2016.00139, doi: 10.3389/fphar.2016.00139/full
  • Subject: EGFR | hypoxia | glioblastoma multiforme invasiveness | RM1-950 | Therapeutics. Pharmacology | PACAP | VIP | HIFs
    mesheuropmc: hormones, hormone substitutes, and hormone antagonists

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This t... View more
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