The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

Article English OPEN
Chen, Yi-Guang; Mathews, Clayton E.; Driver, John P.;
(2018)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Endocrinology,volume 9 (issn: 1664-2392, eissn: 1664-2392)
  • Related identifiers: pmc: PMC5829040, doi: 10.3389/fendo.2018.00051/full, doi: 10.3389/fendo.2018.00051
  • Subject: NOD mouse | congenic | type 1 diabetes | genetics | preclinical | RC648-665 | Perspective | Diseases of the endocrine glands. Clinical endocrinology | gene editing | Endocrinology

For more than 35 years, the NOD mouse has been the primary animal model for studying autoimmune diabetes. During this time, striking similarities to the human disease have been uncovered. In both species, unusual polymorphisms in a major histocompatibility complex (MHC)... View more