publication . Article . 2014

Limitations when use chloramphenicol-bcyclodextrins complexes in ophtalmic solutions buffered with boric acid/borax system

Nicoleta Todoran; Adriana Ciurba; Emőke Rédai; V. Ion; Luminița Lazăr; Emese Sipos;
Open Access English
  • Published: 01 Dec 2014 Journal: Acta Medica Marisiensis (issn: 2247-6113, Copyright policy)
  • Publisher: Sciendo
Abstract
<jats:title>Abstract</jats:title> <jats:p>Chloramphenicol eye drops are commonly prescribed in concentrations of 0.5-1% in the treatment of infectious conjunctivitis. In terms of ophthalmic solution preparation, the major disadvantage of chloramphenicol consists in its low solubility in water. The solubility is increased by substances that form chloramphenicol-complexes, for example: boric acid/borax or cyclodextrins. Objective: Experimental studies aimed to evaluate the potential advantages of enhancing the solubility and stability of chloramphenicol (API) by molecular encapsulation in b-cyclodextrin (CD), in formulation of ophthalmic solutions buffered with bo...
Subjects
free text keywords: chloramphenicol, b-cyclodextrin complexes, ophthalmic solutions, boric acid/borax system, Medicine, R, business.industry, business, medicine.drug, Physical therapy, medicine.medical_specialty, Boric acid, chemistry.chemical_compound, chemistry, Nuclear chemistry, Borax, Biochemistry
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publication . Article . 2014

Limitations when use chloramphenicol-bcyclodextrins complexes in ophtalmic solutions buffered with boric acid/borax system

Nicoleta Todoran; Adriana Ciurba; Emőke Rédai; V. Ion; Luminița Lazăr; Emese Sipos;