publication . Article . 2014

Тhe mass-spectrometry studies of the interaction of polyhexamethyleneguanidine with lipids

A. V. Lysytsya; A. V. Rebriev;
Open Access English
  • Published: 01 Feb 2014 Journal: Ukrainian Biochemical Journal (issn: 2409-4943, eissn: 2413-5003, Copyright policy)
  • Publisher: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
In this work the integral components of the cytoplasmic membrane, lecithin and cholesterol were used for mass spectrometry analysis carried out on polyhexamethyleneguanidine (PHMG) mixtures with lipids. The study was performed by mass-spectrometry methods of the MALDI-TOF MS. Our results showed that despite the common use of PHGM polymer derivatives as disinfectants the persistent intermolecular complexes of PHMG oligomers with lipids were not formed. The binding of polycation PHMG with the membrane has been explained by the model proposed. According to this model PHGM can adhere to negatively charged plasma membrane of bacterial cell due to electrostatic intera...
free text keywords: disinfectant, lipids, mass-spectrometry, membrane destruction, polyhexamethyleneguanidine, Biochemistry, QD415-436
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