Inhibiting TRK Proteins in Clinical Cancer Therapy

Article English OPEN

Allison M. Lange; Hui-Wen Lo;

(2018)

Publisher: MDPI

Journal: Cancers, volume 10, issue 4 (issn: 2072-6694, eissn: 2072-6694)

Publisher copyright policies & self-archiving

Identifiers: pmc: PMC5923360, doi: 10.3390/cancers10040105
Subject: TRKC | TRKA | TRKB | NTRK gene fusions | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | Review | RC254-282 | cancer | tyrosine kinase inhibitor | neurotrophin
mesheuropmc: enzymes and coenzymes (carbohydrates) | animal structures | nervous system | embryonic structures

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer the... View more

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Related Research Results (2)

Inferred by OpenAIRE

dataset Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation (2016)	74%
dataset <i>NTRK1</i> Fusion in Glioblastoma Multiforme (2016)	73%

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