Inhibiting TRK Proteins in Clinical Cancer Therapy
- Published: 01 Apr 2018
- Publisher: MDPI AG
- Wake Forest University, School of Medicine United States
- Wake Forest University United States
- Funder: National Institutes of Health (NIH)
- Project Code: 3R01NS087169-03S1
- Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
1. 2. 3. 4. 5. 6. 7. 8. 9. Drilon, A.; Siena, S.; Ou, S.I.; Patel, M.; Ahn, M.J.; Lee, J.; Bauer, T.M.; Farago, A.F.; Wheler, J.J.; Liu, S.V.; et al. Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1). Cancer Discov. 2017, 7, 400-409. [CrossRef] [PubMed]
Nakagawara, A. Trk receptor tyrosine kinases: A bridge between cancer and neural development. Cancer Lett. 2001, 169, 107-114. [CrossRef] [OpenAIRE]
Lagadec, C.; Meignan, S.; Adriaenssens, E.; Foveau, B.; Vanhecke, E.; Romon, R.; Toillon, R.A.; Oxombre, B.; Hondermarck, H.; Le Bourhis, X. TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 2009, 28, 1960-1970. [CrossRef] [PubMed] [OpenAIRE]
Amatu, A.; Sartore-Bianchi, A.; Siena, S. NTRK gene fusions as novel targets of cancer therapy across multiple tumour types. ESMO Open 2016, 1, e000023. [CrossRef] [PubMed] Ardini, E.; Menichincheri, M.; Banfi, P.; Bosotti, R.; De Ponti, C.; Pulci, R.; Ballinari, D.; Ciomei, M.; Texido, G.; Degrassi, A.; et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol. Cancer Ther. 2016, 15, 628-639. [CrossRef] [PubMed] Allen, S.J.; Wilcock, G.K.; Dawbarn, D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochem. Biophys. Res. Commun. 1999, 264, 648-651. [CrossRef] [PubMed] Hashimoto, T.; Bergen, S.E.; Nguyen, Q.L.; Xu, B.; Monteggia, L.M.; Pierri, J.N.; Sun, Z.; Sampson, A.R.; Lewis, D.A. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J. Neurosci. 2005, 25, 372-383. [CrossRef] [PubMed] Coppola, V.; Barrick, C.A.; Southon, E.A.; Celeste, A.; Wang, K.; Chen, B.; Haddad, E.-B.; Yin, J.; Nussenzweig, A.; Subramaniam, A.; et al. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 2004, 131, 5185-5195. [CrossRef] [PubMed] Singer, H.S.; Hansen, B.; Martinie, D.; Karp, C.L. Mitogenesis in glioblastoma multiforme cell lines: A role for NGF and its TrkA receptors. J. Neurooncol. 1999, 45, 1-8. [CrossRef] [PubMed] [OpenAIRE]
10. Indo, Y.; Mardy, S.; Miura, Y.; Moosa, A.; Ismail, E.A.; Toscano, E.; Andria, G.; Pavone, V.; Brown, D.L.; Brooks, A.; et al. Congenital insensitivity to pain with anhidrosis (CIPA): Novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. Hum. Mutat. 2001, 18, 308-318. [CrossRef] [PubMed]
11. Morgensztern, D.; Campo, M.J.; Dahlberg, S.E.; Doebele, R.C.; Garon, E.; Gerber, D.E.; Goldberg, S.B.; Hammerman, P.S.; Heist, R.S.; Hensing, T.; et al. Molecularly targeted therapies in non-small-cell lung cancer annual update 2014. J. Thorac. Oncol. 2015, 10, S1-S63. [CrossRef] [PubMed] [OpenAIRE]
12. Indo, Y. Neurobiology of pain, interoception and emotional response: Lessons from nerve growth factor-dependent neurons. Eur. J. Neurosci. 2014, 39, 375-391. [CrossRef] [PubMed] [OpenAIRE]
13. Tejeda, G.S.; Diaz-Guerra, M. Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies. Int. J. Mol. Sci. 2017, 18, 268. [CrossRef] [PubMed]
14. Su, A.I.; Wiltshire, T.; Batalov, S.; Lapp, H.; Ching, K.A.; Block, D.; Zhang, J.; Soden, R.; Hayakawa, M.; Kreiman, G.; et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 2004, 101, 6062-6067. [CrossRef] [PubMed]
15. Salehi, A.; Verhaagen, J.; Dijkhuizen, P.A.; Swaab, D.F. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 1996, 75, 373-387. [CrossRef] [OpenAIRE]
16. Ferrer, I.; Marin, C.; Rey, M.J.; Ribalta, T.; Goutan, E.; Blanco, R.; Tolosa, E.; Marti, E. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J. Neuropathol. Exp. Neurol. 1999, 58, 729-739. [CrossRef] [PubMed]
17. Fenner, M.E.; Achim, C.L.; Fenner, B.M. Expression of full-length and truncated TrkB in human striatum and substantia nigra neurons: Implications for Parkinson's disease. J. Mol. Histol. 2014, 45, 349-361. [CrossRef] [PubMed]
18. Krishnan, V.; Nestler, E.J. Linking molecules to mood: New insight into the biology of depression. Am. J. Psychiatry 2010, 167, 1305-1320. [CrossRef] [PubMed]
19. Ernst, C.; Deleva, V.; Deng, X.; Sequeira, A.; Pomarenski, A.; Klempan, T.; Ernst, N.; Quirion, R.; Gratton, A.; Szyf, M.; et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch. Gen. Psychiatry 2009, 66, 22-32. [CrossRef] [PubMed]
20. Dwivedi, Y.; Rizavi, H.S.; Conley, R.R.; Roberts, R.C.; Tamminga, C.A.; Pandey, G.N. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch. Gen. Psychiatry 2003, 60, 804-815. [CrossRef] [PubMed]
Related research
- Wake Forest University, School of Medicine United States
- Wake Forest University United States
- Funder: National Institutes of Health (NIH)
- Project Code: 3R01NS087169-03S1
- Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
1. 2. 3. 4. 5. 6. 7. 8. 9. Drilon, A.; Siena, S.; Ou, S.I.; Patel, M.; Ahn, M.J.; Lee, J.; Bauer, T.M.; Farago, A.F.; Wheler, J.J.; Liu, S.V.; et al. Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1). Cancer Discov. 2017, 7, 400-409. [CrossRef] [PubMed]
Nakagawara, A. Trk receptor tyrosine kinases: A bridge between cancer and neural development. Cancer Lett. 2001, 169, 107-114. [CrossRef] [OpenAIRE]
Lagadec, C.; Meignan, S.; Adriaenssens, E.; Foveau, B.; Vanhecke, E.; Romon, R.; Toillon, R.A.; Oxombre, B.; Hondermarck, H.; Le Bourhis, X. TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 2009, 28, 1960-1970. [CrossRef] [PubMed] [OpenAIRE]
Amatu, A.; Sartore-Bianchi, A.; Siena, S. NTRK gene fusions as novel targets of cancer therapy across multiple tumour types. ESMO Open 2016, 1, e000023. [CrossRef] [PubMed] Ardini, E.; Menichincheri, M.; Banfi, P.; Bosotti, R.; De Ponti, C.; Pulci, R.; Ballinari, D.; Ciomei, M.; Texido, G.; Degrassi, A.; et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol. Cancer Ther. 2016, 15, 628-639. [CrossRef] [PubMed] Allen, S.J.; Wilcock, G.K.; Dawbarn, D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochem. Biophys. Res. Commun. 1999, 264, 648-651. [CrossRef] [PubMed] Hashimoto, T.; Bergen, S.E.; Nguyen, Q.L.; Xu, B.; Monteggia, L.M.; Pierri, J.N.; Sun, Z.; Sampson, A.R.; Lewis, D.A. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J. Neurosci. 2005, 25, 372-383. [CrossRef] [PubMed] Coppola, V.; Barrick, C.A.; Southon, E.A.; Celeste, A.; Wang, K.; Chen, B.; Haddad, E.-B.; Yin, J.; Nussenzweig, A.; Subramaniam, A.; et al. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 2004, 131, 5185-5195. [CrossRef] [PubMed] Singer, H.S.; Hansen, B.; Martinie, D.; Karp, C.L. Mitogenesis in glioblastoma multiforme cell lines: A role for NGF and its TrkA receptors. J. Neurooncol. 1999, 45, 1-8. [CrossRef] [PubMed] [OpenAIRE]
10. Indo, Y.; Mardy, S.; Miura, Y.; Moosa, A.; Ismail, E.A.; Toscano, E.; Andria, G.; Pavone, V.; Brown, D.L.; Brooks, A.; et al. Congenital insensitivity to pain with anhidrosis (CIPA): Novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. Hum. Mutat. 2001, 18, 308-318. [CrossRef] [PubMed]
11. Morgensztern, D.; Campo, M.J.; Dahlberg, S.E.; Doebele, R.C.; Garon, E.; Gerber, D.E.; Goldberg, S.B.; Hammerman, P.S.; Heist, R.S.; Hensing, T.; et al. Molecularly targeted therapies in non-small-cell lung cancer annual update 2014. J. Thorac. Oncol. 2015, 10, S1-S63. [CrossRef] [PubMed] [OpenAIRE]
12. Indo, Y. Neurobiology of pain, interoception and emotional response: Lessons from nerve growth factor-dependent neurons. Eur. J. Neurosci. 2014, 39, 375-391. [CrossRef] [PubMed] [OpenAIRE]
13. Tejeda, G.S.; Diaz-Guerra, M. Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies. Int. J. Mol. Sci. 2017, 18, 268. [CrossRef] [PubMed]
14. Su, A.I.; Wiltshire, T.; Batalov, S.; Lapp, H.; Ching, K.A.; Block, D.; Zhang, J.; Soden, R.; Hayakawa, M.; Kreiman, G.; et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 2004, 101, 6062-6067. [CrossRef] [PubMed]
15. Salehi, A.; Verhaagen, J.; Dijkhuizen, P.A.; Swaab, D.F. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 1996, 75, 373-387. [CrossRef] [OpenAIRE]
16. Ferrer, I.; Marin, C.; Rey, M.J.; Ribalta, T.; Goutan, E.; Blanco, R.; Tolosa, E.; Marti, E. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J. Neuropathol. Exp. Neurol. 1999, 58, 729-739. [CrossRef] [PubMed]
17. Fenner, M.E.; Achim, C.L.; Fenner, B.M. Expression of full-length and truncated TrkB in human striatum and substantia nigra neurons: Implications for Parkinson's disease. J. Mol. Histol. 2014, 45, 349-361. [CrossRef] [PubMed]
18. Krishnan, V.; Nestler, E.J. Linking molecules to mood: New insight into the biology of depression. Am. J. Psychiatry 2010, 167, 1305-1320. [CrossRef] [PubMed]
19. Ernst, C.; Deleva, V.; Deng, X.; Sequeira, A.; Pomarenski, A.; Klempan, T.; Ernst, N.; Quirion, R.; Gratton, A.; Szyf, M.; et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch. Gen. Psychiatry 2009, 66, 22-32. [CrossRef] [PubMed]
20. Dwivedi, Y.; Rizavi, H.S.; Conley, R.R.; Roberts, R.C.; Tamminga, C.A.; Pandey, G.N. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch. Gen. Psychiatry 2003, 60, 804-815. [CrossRef] [PubMed]