Inhibiting TRK Proteins in Clinical Cancer Therapy

Article English OPEN

Allison M. Lange; Hui-Wen Lo;

(2018)

Publisher: MDPI

Journal: Cancers,volume 10,issue 4 (issn: 2072-6694, eissn: 2072-6694)

Publisher copyright policies & self-archiving

Related identifiers: pmc: PMC5923360, doi: 10.3390/cancers10040105
Subject: TRKC | TRKA | TRKB | NTRK gene fusions | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | Review | RC254-282 | cancer | tyrosine kinase inhibitor | neurotrophin
mesheuropmc: enzymes and coenzymes (carbohydrates) | animal structures | nervous system | embryonic structures

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer the... View more

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Related Research Results (2)

Inferred

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation (2013)	74%
<i>NTRK1</i> Fusion in Glioblastoma Multiforme (2014)	73%

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