Inhibiting TRK Proteins in Clinical Cancer Therapy

Article English OPEN
Allison M. Lange; Hui-Wen Lo;
  • Publisher: MDPI
  • Journal: Cancers, volume 10, issue 4 (issn: 2072-6694, eissn: 2072-6694)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC5923360, doi: 10.3390/cancers10040105
  • Subject: TRKC | TRKA | TRKB | NTRK gene fusions | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | Review | RC254-282 | cancer | tyrosine kinase inhibitor | neurotrophin
    mesheuropmc: enzymes and coenzymes (carbohydrates) | animal structures | nervous system | embryonic structures

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer the... View more
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