publication . Article . 2014

Serum-Free Media and the Immunoregulatory Properties of Mesenchymal Stem Cells In Vivo and In Vitro

Mei Wu; Zhi-Bo Han; Jun Feng Liu; You Wei Wang; Jian Zhong Zhang; Chun Tuan Li; Peng Liang Xin; Zhong Chao Han; Xiong Peng Zhu;
Open Access
  • Published: 01 Feb 2014 Journal: Cellular Physiology and Biochemistry, volume 33, pages 569-580 (issn: 1015-8987, eissn: 1421-9778, Copyright policy)
  • Publisher: S. Karger AG
Abstract
Background: Mesenchymal stem cells are capable of self-renewal and multi-lineage differentiation. They are used extensively to treat several diseases. Traditionally, mesenchymal stem cells are cultured in serum-containing media, typically supplemented with fetal bovine serum (FBS). However, the variability of FBS is likely to skew experimental results. Although serum-free media used to expand mesenchymal stem cells has facilitated remarkable achievements, immunomodulation of these cells in under serum-free conditions is poorly understood. We hypothesized that mesenchymal stem cells expanded in serum-free media will retain powerful immunoregulatory functions in v...
Subjects
free text keywords: Physiology, Stem cell, Cell biology, Adult stem cell, Amniotic stem cells, Immunology, Cancer stem cell, Mesenchymal stem cell, Endothelial stem cell, Biochemistry, Stem cell transplantation for articular cartilage repair, Clinical uses of mesenchymal stem cells, Biology, Mesenchymal stem cells, Umbilical cord, Serum-free media, Immunomodulation, QP1-981, QD415-436
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